Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

As a result of long-term clinical research on former prisoners of the Nazi concentration camps, I analyzed the evolution of the clinical and psychopathological pattern of the KZ-syndrome. One can differentiate the following characteristic phases: psychosomatic inanition, latency of disease, personality and adaptation disturbances, a pseudo-neurotic and depressive phase, premature aging, and an organic phase. The stigma of KZ-syndrome is present in a second generation in different forms: personality disturbances, emotional and/or social immaturity, social disadaptation, higher frequency of neurotic states, divorce, alcoholism, and suicide. The camp stress has left in human nature traces so painful that they cannot disappear when the generation of former prisoners is gone.
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PMID:The evolution of mental disturbances in the concentration camp syndrome (KZ-syndrom). 218 95

It appears certain that the causes of self-destructive dermatoses are many and complex. The disorder spans diagnostic categories and varies from unconscious picking at the skin to severe self-destructive actions. Although not limited to any one diagnosis, skin disorders appear to be more prevalent in depression. This association may involve activation of the hypothalamic-pituitary-adrenal axis commonly found in depression. Two specific types of commonly occurring dermatoses-neurotic excoriations and dermatitis artefacta-are reviewed in this article. The major distinction of these disorders centers on whether the patient can admit to self-mutilation. Because of the difficulties in dermatitis artefacta with insight and body-image, it has been compared with anorexia nervosa. Often, dermatitis artefacta coexists with anorexia nervosa. In both disorders, neurotic excoriations and dermatitis artefacta, the personality style tends to be introverted with emotional immaturity. These patients have difficulty when they are under stress; the problem is compounded because of poor communication skills. Pharmacotherapy is of limited usefulness, and psychotherapy is often times hindered by strong resistance to exploring long-standing emotional issues. Once an alliance is established with the therapist, however, these issues may be examined. Prognosis is variable but does seem to directly correlate with the duration of the illness. Young individuals may experience alleviation of symptoms after one session of psychotherapy, whereas older patients may never have resolution. Dermatologic abuse involving psychosis has many presentations; one of the most common involves infestation. Organic causes must always be excluded as part of the differential diagnosis. In schizophrenia, this presentation has one of the highest incidences of suicide.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Self-destructive dermatoses. 389 93

The authors review the literature pertaining to the roles of psychopathology and personality variables in traffic accidents. They review studies of nonpsychiatric and psychiatric samples and examine the roles of suicide, life events, alcohol, and drugs. Certain personality characteristics and psychopathology--such as low tension tolerance, immaturity, personality disorder, and paranoid conditions--appear to be risk factors for traffic accidents. Although the role of alcohol is relatively well established, the roles of most other drugs are less clear. The results of further investigation of psychopathology's role in traffic accidents may have implications for prevention.
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PMID:Psychiatric aspects of traffic accidents. 398 93

This work examines the symptomatology of 4 young men recently drafted into military service in France who had negative reactions to their partner's abortions. The men ranged in age from 19-21 years. In all cases there was frank depression, accompanied or not by activity illegal in the eyes of the military (unauthorized leave) or of the common law (theft, use of drugs). The abortion was either a pretext for a rapid decompensation of a pathological personality, or it occasioned a crisis in personalities previously relatively well adapted despite immaturity, psychopathology, or weakness. The organization of the couples tended to be recent, unstable, precarious, and without a promising future either affectively or socioeconomically. Either the woman decided to seek an abortion herself and presented the father with an accomplished fact, or the couple tacitly made a joint decision to seek an abortion, in which case the subsequent illegal activity of the father tended to be more serious. Each of the men had conflictive family relationships with their fathers especially perceived as hostile and rejecting. All of the men had attempted suicide or had considered it. Induction into the army has traditionally been seen as a rite of passage to adult life, but in some cases the emotional distances it causes and the socioeconomic difficulties it aggravates prevent the man from undertaking the responsibilities of fatherhood. In these cases it is as if social maturity can be acquired only at the expense of fatherhood; the 2 states cannot coexist. Frustration and sacrifice of fatherhood nevertheless may occasion loss of the social maturity stemming from military service. The abortion is followed by guilt, psychic suffering, and behavioral problems leading to expulsion from the military. On the symbolic level the man does not become either man or father. Another point is that depression, anxiety, and guilt are an affective expression of the idea of death; the embryo is thought of as an infant when in fact it is only potentially an infant. On the unconscious level the father may identify with the aborted fetus in the belief that his own parents may have wanted to destroy him. The abortion may also contain a suicidal element to the extent that the fetus represents a prolongation of the parent. The anxiety and guilt of the father find expression also in auto- and heteroaggressive acts. Through a mechanism of projection, responsibility of the army is substituted for that of the individual.
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PMID:[Psychological aspects of voluntary induced abortion among fathers drafted into military service]. 1226 37

Suicide in children and young adolescents up to 14 years of age has increased in many countries, warranting research and clinical awareness. International reported suicide rates per 100,000 in this young population vary between 3.1 and 0 (mean rate worldwide, approximately 0.6/100.000; male-female ratio, 2:1). Suicide occurs only in vulnerable children; this vulnerability begins with parental mood disorder and impulsive aggression, and family history of suicide. Childhood affective and disruptive disorders and abuse are the most often reported psychiatric risk factors. Suicide becomes increasingly common after puberty, most probably because of pubertal onset of depression and substance abuse, which substantially aggravate suicide risk. Biologic findings are scarce; however, serotonergic dysfunction is assumed. The most common precipitants are school and family problems and may include actual/anticipated transitions in these environments. Suicides in children and young adolescents up to 14 years of age often follow a brief period of stress. Cognitive immaturity/misjudgment, age-related impulsivity, and availability of suicide methods play an important role. Psychologic autopsy studies that focus on suicides in this age group are needed.
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PMID:Completed suicide in childhood. 1843 49

Laws in Belgium and The Netherlands permit euthanasia and assisted suicide for seriously ill children who experience "constant and unbearable suffering"--they have the capacity to request death by lethal injection if they convey a "reasonable understanding of the consequences" of that request. The child's capacity to understand death is therefore a prerequisite to the implementation of the request. However, modern neuro-psychological and fMRI (functional Magnetic Resonance Imaging) studies of the relationship between the neuro-anatomical development of the brain in human beings and their emotional and experiential capacity demonstrates that both are not fully developed until the early 20s for girls and mid-20s for boys. Unlike Belgium and The Netherlands, the clinical and legal implications of the immaturity of the brain on medical decision-making of minors, in particular life and death decisions, have been implicit in the Australian courts' approach to the refusal of life-saving and life-sustaining treatment by minors. This approach is exemplified by X v Sydney Children's Hospitals Network [2013] NSWCA 320 (and a series of earlier cases).
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PMID:Minors' decision-making capacity to refuse life-saving and life-sustaining treatment: legal and psychiatric perspectives. 2508 58