Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Electrocardiographic findings are analyzed out of a total of 80 exanguinotransfusion done in 70 newborns complaining of hyperbilirubinemia due to isoimmunization to Rh factor, to blood group, to subgroup and to liver enzymatic immaturity. Twenty-six of these babies showed subnormal weights. The technique used was especially that of closed circuit with two vessels and continuous droping. Seventeen patients with concomitant respiratory insuficiency were exanguinated. Electrocardiographic disorders were found in 70% with predominance of hypocalcemia --19 cases--and tachycardia in 9 cases. There were no cases of true hyperkalemia, even in the group of patients who were given blood of over three days of extraction. There were 5 cases of hypokalemia; another 5 with overload in right cavities as possible response to hypervolemia. Disorders of rhythm, bradycardia, ischemia lesions and A-V blockage were present as features of poor prognosis in the only two patients who died in one of whom hyperkalemia and in the other one, hypokalemia were identified. Stress is placed on the greater number of disorders present in the group of infants with subnormal weights, as in those affected with added respiratory insufficiencies or with severe hemolytic diseases.
 ...
PMID:[Electrocardiographic disorders during sanguinotransfusion]. 87 34

Plasma and urinary furosemide kinetics were assayed by high-power liquid chromatography in six newborn infants receiving furosemide (1 mg/kg body weight IV) for the treatment of fluid overload. Mean +/- SD for plasma half-life, apparent volume of distribution, and plasma clearance were, respectively, 9.5 +/- 4.4 hours, 173 +/- 28 ml/kg, and 15.3 +/- 8.4 ml/hr/kg. There was close correspondence between plasma and urinary half-lives and between plasma clearance and renal clearance. In the first 24 hours, mean estimated urinary recovery of unchanged furosemide was 90% of the injected dose (range 61% to 106%). The results suggest that in the newborn infant furosemide is virtually all excreted unchanged in the urine and that the absence of significant nonrenal elimination, together with the immaturity of neonatal renal function, accounts for its prolonged half-life in newborn infants.
 ...
PMID:Plasma and urinary kinetics of furosemide in newborn infants. 688 18

Treating acute kidney injury (AKI) in newborns is often challenging due to the functional immaturity of the neonatal kidney. Because of this physiological limitation, renal replacement therapy (RRT) in this particular patient population is difficult to execute and may lead to unwanted complications. Although fluid overload and electrolyte abnormalities, as seen in neonatal AKI, are indications for RRT initiation, there is limited evidence that RRT initiated in the first year of life improves long-term outcome. The underlying cause of AKI in a newborn patient should determine the treatment strategies to restore appropriate renal function. However, our understanding of this common clinical condition remains limited, as no standardized, evidence-based definition of neonatal AKI currently exists. Non-dialytic management of AKI in these patients may restore appropriate renal function to these patients without exposure to complications often encountered with RRT.
 ...
PMID:Non-dialytic management of acute kidney injury in newborns. 2848 64