Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Human T lymphocytes bear characteristic membrane antigens which allow for identification on these cells and their subpopulations with monoclonal antibody reagents directed against the specific cell-surface antigens. During a study of T lymphocyte subpopulations in a group of 41 infants from a high risk nursery, three of the seven black infants studied were found to be missing cells reactive with the monoclonal antibody OKT4 which identifies the helper-inducer subset of T cells. Immunological evaluation of these infants and study of their family members revealed that the OKT4 non-reactive lymphocytes reacted normally with another antibody, OKT4A, which also identifies the helper-inducer subset of T cells. The deficiency of the antigen recognized by the OKT4 antibody appeared not to reflect T cell immaturity and was not associated with obvious immunodeficiency. The OKT4 negative phenotype appeared to be transmitted in an autosomal recessive mode. Our studies suggest that heterozygosity for this phenotype is relatively common among the black population and that heterozygotes are not easily distinguishable from the random population on the basis of lymphocyte reactivity with the OKT4 monoclonal antibody.
Thymus 1985
PMID:Ethnic heterogeneity in the distribution of the OKT4 antigen on lymphocytes: studies in three black families. 393 38

A modified centrifugal elutriation technique was used to separate (up to 3 X 10(9)) human thymocytes, according to size in 6 different fractions. Eighty percent of the unfractionated thymocytes were recovered in fractions 1 and 2. The majority of these thymocytes appeared to be small and phenotypically immature as was determined by the high percentage of cells reacting with the monoclonal antibodies OKT-6, Mas-036 and peanut agglutinin. In addition, a relatively low percentage of the cells reacted with a monoclonal antibody directed against HLA-A, B and C determinants (Mas-015). The immaturity of these thymocytes was confirmed by their failure to respond to phytohemagglutinin (PHA) and their negligible responder capacity in mixed leukocyte cultures. Fractions 3-6, representing 20% of the unfractionated thymocytes, were collected arbitrarily and contained thymocytes of various maturation stages as judged by their phenotype. The PHA responsiveness and responder capacity in mixed leukocyte cultures of the thymocytes in these fractions were, in general, considerably higher than those of the unfractionated thymocytes. Our data indicate that centrifugal elutriation is a fast and reproducible method to separate large quantities of functionally inactive and phenotypically immature thymocytes from the more mature and functionally active thymocytes.
Thymus 1982 Jul
PMID:Isolation of human thymocytes differing in maturation state and function by centrifugal elutriation. 621 35

The results of this study show that a high percentage of human cord-blood lymphocytes bears receptors for peanut agglutinin. Determination of the presence of other lymphocyte markers (E rosettes, membrane immunoglobulins, alpha-naphthyl-acetate esterase, Ia antigens) in the peanut-positive cells indicated that they include both T and B cells. The peanut receptor, also expressed by blast cells of most acute, but not chronic, leukemias, seems to be a marker of immaturity for both T- and B-lymphocyte subsets in man as it is in the mouse.
Thymus 1981 Apr
PMID:Receptors for peanut agglutinin on a high percentage of human cord-blood lymphocytes: phenotype characterization of peanut-positive cells. 697 44