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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two hundred twenty newborn infants with one or more fetal or newborn complications and 54 newborn infants without fetal or newborn complications were prospectively studied to assess the relationship between maternal, obstetric, fetal, and newborn complications and intracranial hemorrhage. Intracranial hemorrhage occurred in 47 newborn infants with fetal or newborn complications (21%) and in one infant with no fetal or newborn complications (2%). Maternal and obstetric complications, duration of labor, and mode of delivery were not associated with intracranial hemorrhage. Newborn immaturity at delivery is an important factor in the occurrence of intracranial hemorrhage. There is little evidence that fetal hypoxia is a contributing factor. Severe respiratory complications and major infections are newborn complications associated with intracranial hemorrhage.
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PMID:Maternal, fetal, and newborn complications associated with newborn intracranial hemorrhage. 394 21

Fetal and neonatal complications in chorangiomas of different size, in multiple chorangiomas and in cases accompanied with hydramnios were reviewed in 110 cases from literature inclusively 7 own observations. In accordance with other examiners we found an increasing perinatal mortality, especially of the antenatal mortality rate corresponding with an increasing tumor size. Chorangiomas with hydramnios had a mortality of 80 per cent. In these cases only a small part was caused by fetal immaturity or severe malformations. Comparing mean placental weight and mean neonatal weight small for date babies had a relative and absolute augmentation of placental tissue in relation to a control group. The conclusion from these findings and the fact that in own cases heavy disorders of villous differentiation could be observed is, that the fetal fate may be fundamentally influenced not only by the hemodynamic disturbance caused by the tumor, but also by the degree of placental differentiation. Large hemangiomas are ought to detect during pregnancy by ultrasound. In singular cases it may be to prevent fetal hypoxia by termination of pregnancy.
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PMID:[Chorangiomas (hemangiomas of the placenta). II. Pathologic-anatomic comparison of neonatal complications]. 654 34

Infective Endocarditis (IE) during pregnancy is a rare but grave condition. The diagnosis and management can be challenging, especially when the pregnant patient warrants a cardiac operation under cardiopulmonary bypass. The present article describes IE during pregnancy based on a series of published case reports in the literature. IE during pregnancy often causes embolic events and mycotic aneurysms. Two-thirds of IE in the pregnant patients requires timely or urgent cardiac surgery to alleviate patients' deterioration. At least a 3-week antibiotic therapy is mandatory before cardiac surgery aiming at improving the patients' conditions. During cardiac surgery, fetal heart rates may temporarily be slowed down but may gradually recover to normal after the operation. The fetal and maternal mortalities were 16.7% and 3.3%, respectively. The fetal deaths were apparently associated with a cardiac surgery during early pregnancy. Cardiopulmonary bypass, hypothermia and rewarming can adversely affect both the mother and the fetus by triggering placental deficits, fetal hypoxia and uterine contraction. Avoidance of cardiac operations before 24th gestation week and preferably deferred until after 28th gestation week have been a plausible argument as per the possible fetal deaths related to immaturity.
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PMID:Infective Endocarditis during pregnancy. 2570 59

Nowadays, the continuous rise of maternal obesity is followed by increased gestational diabetes mellitus incidence. GDM is associated with adverse fetal and neonatal outcome that often presents with macrosomia, birth trauma, neonatal hypoglycemia, and respiratory distress syndrome. Inclusion of GDM into 'the great obstetrical syndromes' emphasizes the role of the placenta in interactions of the maternal and fetal unit. The placenta acts as a natural selective barrier between maternal and fetal blood circulations. Placenta is sensitive to the hyperglycemic milieu and responses with adaptive changes of the structure and function. Alteration of the placental development and subsequent vascular dysfunction are presented in 6 out of 7 women with all ranges of diabetic severity. Most placentas from GDM pregnancies present typical histological findings such as villous immaturity, villous fibrinoid necrosis, chorangiosis, and increased angiogenesis. The type of dysfunction depends on how early in pregnancy glycaemia disorders occurred. Generally, if impaired glucose metabolism is diagnosed in the early pregnancy, mainly structural dysfunctions are observed. GDM that is detected in late gestation affects placental function to a greater extent. Moreover many studies suggest that diabetic placental changes are associated with inflammation and oxidative stress that can lead to the chronic fetal hypoxia. This article aims to review particular changes of the development, anatomy and function of the placenta in the environment of abnormal glucose metabolism which can establish the maternal-placental-fetal interface dysfunction as a potential source of adverse pregnancy outcomes. A detailed sequence of events that leads from hyperglycemia to placental dysfunction and subsequent pregnancy complications may become an important issue for further studies.
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PMID:Placental pathologic changes in gestational diabetes mellitus. 2607 74