Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029713 (
immaturity
)
4,335
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Megakaryocytic disorders induce serious consequences: myelofibrosis and
osteomyelosclerosis
, hemorrhage, and thrombosis. They are characterized by four main structural types: myeloproliferation, dysmegakaryocytosis, amegakaryocytosis, and secondary megakaryocytosis. Whereas the first and third are primarily defined by histology, the second and fourth are to be interpreted only in the context of clinical findings. Nevertheless, bone marrow biopsy has revealed marked quantitative and qualitative anomalies of megakaryocytes also in these groups: isolation, pleomorphism, and degeneration of nuclei, and
immaturity
, vacuolization, and disruption of cytoplasm. The pathophysiologic impact of these impressive changes is almost unknown. It deserves further consideration.
...
PMID:Bone marrow in megakaryocytic disorders. 306 25
