Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A monoclonal gammopathy (M.G.) is usually associated with multiple myeloma or macroglobulinemia. Cases whose follow up have not demonstrated myeloma or lymphoma for several years are called "benign monoclonal gammopathies" (B.M.G.). Numerous criteria were suggested to distinguish multiple myeloma from B.M.G., chiefly an abnormal medullary plasmacytosis. But frequently it is only beyond 15 to 20 % that this plasmacytosis is considered as significative. Some authors have reported the peculiarities of these plasma cells immune labelling with rather conflicting results. We reviewed semi-thin sections of bone marrow biopsies with a low grade plasmacytosis (less than or equal to 10 %) by histological cytological and immunological methods in a group of 39 patients with a M.G. A diagnosis of multiple myeloma or of B.M.G. was made on the initial examination of these biopsies. The 24 cases of multiple myeloma were diagnosed using : --topographical criteria : inhomogenous sharing, nests of plasmocytes exclusively away from the periphery of vessels, --cytological criteria such as frequent cellular immaturity, nuclear immaturity in binucleated cells, bizarre shaped nuclei . . . --immunological criteria obtained by immunofluorescence method : strictly monoclonal labelling of plasma cells or "limit"-monoclonal labelling in 50 % of cases. The latter is less characteristic because of its presence in 25 % of B.M.G. In this prospective study, the initial diagnosis was maintained in 37 out of the 39 cases according to clinical and laboratory data. These results seem to demonstrate the practical value of the proposed criteria.
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PMID:[Interpretation of minimal medullary plasmacytoses in monoclonal dysglobulinemias. Importance of the study of osteomedullary biopsies of semi-thin sections and immunologic marking]. 676 Aug 76

The criteria of the Polycythemia Vera Study Group (PVSG), although acknowledged as the gold standard to establish the diagnosis of polycythemia vera (PV), do not regard bone marrow (BM) histopathology. Arguments include the existence of sufficient objective markers of disease and the lack of independently performed morphological studies or standardized criteria. The aim of this review is to evaluate morphological characteristics of erythrocytosis and to determine whether distinctive patterns of histopathology exist. A review of the pertinent literature and evaluation of 334 patients from our files with a borderline to marked increase in hemoglobin was performed. In extension to former descriptions of BM features by the PVSG, a tri-lineage myeloproliferation (panmyelosis) with a pleomorphous appearance of megakaryopoiesis revealed that, besides increase in size, there was a lack of gross cytological anomalies. Differentiation from secondary polycythemia (SP) was accomplished by regarding these features and the conspicuously expressed stromal changes (plasmacytosis, eosinophils, cell debris and iron deposits). In about 96% of this cohort a clear-cut separation from SP was achieved, even in the initial (latent) stages. When accompanied by an elevated platelet count, these precursor stages may clinically mimick essential thrombocythemia because they are not recognized by the conventional criteria. Advanced stages (spent phases) of PV were consistent with an increased left-shifted granulocytic proliferation, accompanied by reduction of erythroid precursors and progressive myelofibrosis (post-polycythemic myeloid metaplasia). Finally, an increase in dysplastic changes and immaturity signalled a transition into blastic crisis. In conclusion, PV is characterized by a distinctive pattern of histopathology that has been gained in an independent and blind fashion and therefore, dissolves arguments about failing specificity.
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PMID:Diagnostic impact of bone marrow histopathology in polycythemia vera (PV). 1557 48

The diagnostic criteria of the Polycythemia Vera Study Group do not consider bone marrow histopathology, nor do they recognize the dynamics of polycythemia vera (PV). Precursor stages, when accompanied by an elevated platelet count, may clinically mimic essential thrombocythemia. Significantly extending former descriptions of bone marrow features, a trilineage myeloproliferation (panmyelosis) with a pleomorphous appearance (differences in size) of megakaryopoiesis is a characteristic histopathologic finding in PV. Differentiation from secondary polycythemia is accomplished by also considering the conspicuously expressed stromal changes (perivascular plasmacytosis, eosinophils, cell debris, and iron deposits). A clear-cut discrimination is possible, even in the initial (latent) stages of PV, which do not fulfill all the conventional diagnostic criteria. Advanced stages (spent phases) of PV show an increased left-shifted granulocytic proliferation accompanied by reduction of erythroid precursors and progressive myelofibrosis (postpolycythemic myeloid metaplasia). Finally, an increase in dysplastic changes and immaturity of cell lineages signals a transition into blastic crisis.
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PMID:Is it justified to perform a bone marrow biopsy examination in sustained erythrocytosis? 2042 37