Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied the role of receptors with high and low affinity for fMLF chemotaxic peptide in the generation of active oxygen species by umbilical cord blood granulocytes from newborns with normal neonatal period, born after normal or complicated gestation, in children with manifestations of bacterial infection born after complicated pregnancy, and in granulocytes of non-pregnant women with normal reproductive function. Granulocytes of children born after complicated pregnancy exhibited high reactivity in induction of respiratory burst in a wide range of fMLF concentrations. The presentation of receptors with high and low affinity on granulocytes during initiation of the respiratory burst differs in children born after complicated pregnancy and in healthy babies born after normal gestation. Presumably, the detected differences result from high expression of receptors with low affinity for fMLF and disorders or immaturity of mechanisms responsible for receptor inactivation.
 ...
PMID:Evaluation of the Role of FMLF chemotaxic peptide receptors in umbilical cord blood granulocytes from newborns at risk of infectious inflammatory diseases. 1911 May 92

The aim of this study was to identify risk factors for neurological development in children aged 1 to 3 years with a mild paraparesis form of motor development of lower extremities. Identification and follow-up of the neurorisk factors is important for early detection of neurodevelopmental deviations as well as for initiating early therapeutic treatments, which can improve the processes of brain plasticity and lead to recovery of the damaged function. Analysis of risk factors in children with paraparesis form of development revealed complicated pregnancy such as maternal diseases, fetal growth retardation or placental immaturity in 48% of these children; 26% of children were born before or after the term, and 34% had complications during delivery such as cesarean section or breech birth. In the present study, 80% of children with motor disabilities of lower extremities had Apgar index 10, 8% Apgar index 9, and only 12% had Apgar index lower than 8. Only 10% of 50 study children had normal ultrasound results, whereas cranial ultrasound abnormalities such as periventricular hemorrhage and intraventricular hemorrhage were recorded in 62% of the children.
 ...
PMID:Risk factors for gross motor dysfunction of lower limbs in children. 2238 71