Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute leukemia in the newborn child is a rare event. The clinical and biological characteristics differ from those normally encountered in the older child. Tumoral syndrome and extra-medullar locations are frequently described in the literature. Many authors have noted the difficulty of diagnosis due to the immaturity of the malignant proliferation. While it is generally agreed that therapeutic abstention is justified in the leukemoid reaction in Down's syndrome, the choice is debatable in the phenotypically intact newborn. For this reason, blastic karyotype analysis is essential and may provide guidelines when considering treatment. We report on a case history of acute monoblastic leukemia with translocation 9;11 that was diagnosed at birth in a normal newborn infant. The juxtaposition of c-ets 1 protooncogene and the beta-interferon gene has been associated with this kind of cytogenetic disease and probably constitutes a model for human leukemogenesis.
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PMID:[Acute congenital monoblastic leukemia and 9;11 translocation: a case]. 133 93

A case of lepromatous leprosy with erythema nodosum leprosum (ENL) presenting as a myeloid leukemoid reaction is reported. Very high leucocyte count with immaturity of the cells in myeloid series was present in peripheral blood. High leucocyte alkaline phosphatase score, absence of hepatosplenomegaly and transient nature of leukemoid reaction differentiated it from chronic myeloid leukemia and acute myeloblastic leukemia. The possible mechanisms of leukemoid reaction in ENL are discussed.
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PMID:Leukemoid reaction in erythema nodosum leprosum in a leprosy patient. 325 36

A 3 1/2-year-old dog with extensive tumor metastases to the lungs was found to have neutrophilic leukocytosis termed a leukemoid reaction. The term leukemoid reaction describes an absolute increase in the blood leukocyte concentration without regard to a predominant cell type or to the degree of cell immaturity. These types of reactions are extremely difficult to differentiate from leukemia. Leukemoid reactions can be acute or chronic and they may have an infectious, inflammatory, toxic, or neoplastic origin. Those reactions attributable to neoplasia have been documented in medical literature, but the mechanism causing the granulocytosis has not always been clearly understood. A granulopoietin capable of stimulating a leukemoid reaction may be elaborated by certain types of tumors, tumors with extensive metastasis, or tumors involving the lungs, liver, or stomach.
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PMID:Neutrophilic leukocytosis associated with metastatic fibrosarcoma in a dog. 387 53

A hematological picture simulating that seen in cases of leukemia often occurs in a variety of conditions. We recently treated a patient who had a leukemoid reaction in the peripheral blood while he was on parenteral nutrition. Throughout the period of treatment with parenteral nutrition, an abnormal shift towards immaturity in the neutrophilic granulocytes was seen, and the degree of this shift appeared to depend on the caloric intake. Moreover, the hematological picture resembling that seen in cases of leukemia disappeared shortly after discontinuation of the parenteral nutrition, and immature cells were no longer apparent. We assumed that the excess glucose-related calories included in parenteral nutrition produced the leukemoid reaction in this patient who was being surgically treated for carcinoma of the colon with hepatic metastasis.
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PMID:Leukemoid reaction associated with parenteral nutrition. 679 18