Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029713 (
immaturity
)
4,335
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Fifteen patients presenting with
plasma cell leukemia
(
PCL
) are reported in detail. The clinicopathologic features of
PCL
differ from typical myeloma and resemble those of acute leukemia: patients with
PCL
have less bone disease but a much higher incidence of organomegaly and tissue infiltration as well as diffuse marrow involvement and more pronounced pancytopenia. One of the reported patients developed meningeal
plasma cell leukemia
and is reported in detail. Cytomorphologic assessment of
PCL
cells showed nuclear
immaturity
and obvious nuclear/cytoplasmic asynchrony. Despite the use of cytotoxic agents known to be effective in myeloma, the prognosis in
PCL
is poor, and the median survival of the reported patients was only 2 mo.
...
PMID:Plasma cell leukemia (PCL): A report on 15 patients. 68 31
