Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029713 (immaturity)
 4,335 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The clinical effects and therapeutic value of a 500 mg implant of oestradiol benzoate was observed in thirty-nine Thoroughbred brood mares showing various abnormalities of the ovary and/or the reproductive tract. Sixteen similarly affected, untreated mares acted as controls. The implant was inserted during the early part of the normal anoestrous period and was removed 6 to 10 weeks later. The conception rate among the treated group (59%) during the onset of the ensuing breeding season was significantly higher (P less than 0-02) than that in the control group. The value of this form of treatment in septic endometritis and as an anabolic aid in cases of immaturity is also discussed.
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PMID:Some clinical observations on the effect of an implant of oestradiol benzoate in brood mares. 106 Jul 94

Sixty-one patients with preterm rupture of membranes were studied. Transabdominal amniocentesis was performed successfully in 42 patients (68.8%). Among these 42, 26 (61.9%) had a lecithin:sphingomyelin (L:S) ratio of 1.8 or greater and 16 (38.1%) demonstrated pulmonary immaturity. Amniotic fluid obtained from vaginal pooling was compared to fluid obtained transabdominally in seven patients and did not demonstrate any significant differences in L:S values. Gram stain and subsequent culturing of amniotic fluid obtained transabdominally was accomplished in 41 patients. Seven of the 41 patients (17.0%) had bacteria on Gram stain and/or subsequent amniotic fluid growth. All patients with either bacteria on Gram stain or a positive amniotic fluid culture developed clinical amnionitis or endometritis. Review of the neonatal morbidity and mortality in relation to gestational age of infants with preterm rupture of membranes suggests that: 1) In infants at less than 32 weeks' gestation, amniocentesis need not be done for pulmonary maturity as the morbidity of prematurity in this group is too high even in the presence of pulmonary maturity. 2) In infants at 32 to 34 weeks' gestation, amniocentesis for L:S ratio, Gram stain, and culture is helpful in selecting those in whom delivery should be instituted. 3) In infants at greater than 34 weeks' gestation, the neonatal morbidity is sufficiently reduced so that delivery should be considered except in cases of suspected delayed pulmonary maturation.
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PMID:Use of amniocentesis in preterm gestation with ruptured membranes. 669 Oct 16