Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0029463 (osteosarcoma)
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Human Gene/Protein
hypothetical protein FLJ20343 10.9
deleted in lung and esophageal cancer protein 1 10.9
large multifunctional protease 7 10.9
osteosarcoma 10.9
5033414D02Rik 10.9
HIST1H2AI 10.9
synuclein, gamma 10.9
ribosomal RNA processing 12 homolog 10.9
PLA2G16 protein 10.9
AROS-29 10.9
Transforming growth factor beta regulator 4 10.9
KIAA0427 10.9
SNRNP25 10.3
HOS 10.0
scotin 9.9
EIF4G2 protein 9.9
wingless-type MMTV integration site family, member 5B 9.9
VMO1 9.9
Zinc finger protein 281 9.9
MSTO2P 9.9
C3orf35 9.9
ZNF768 9.9
rho family, small GTP binding protein Rac1 9.9
FAM45A 9.9
SRGAP2 protein 9.9
GCP-1 9.9
ADCK2 9.9
SPON1 protein 9.9
19kD) 9.9
PRPSAP2 9.9
transmembrane protein 35 9.9
ANKMY1 9.9
centrosomal colon cancer autoantigen protein 9.9
Glutamate receptor, metabotropic 4 9.9
FGFRL1 protein 9.9
tripartite motif-containing 66 9.9
SARG 9.6
Fer-1-like protein 4 9.6
COPS3 9.5
mitogen-activated protein kinase kinase kinase 9 9.3
KRTAP10-1 9.3
FAM83G 9.3
FRAG1 9.3
neighbor of BRCA1 gene 2 9.3
hCAF-1 9.3
BRCC2 9.3
RAB39A 9.3
PDZ domain containing 2 9.3
G protein-coupled receptor 110 9.3
GTF2A2 9.3
Homeobox B7 9.3
Armadillo repeat-containing protein 8 9.3
KIAA0495 9.3
p21-activated kinase 7 9.3
CORS-26 9.3
WD repeat-containing protein 7 9.3
kin of IRRE like 9.3
PLCE 9.3
GPR172A 9.3
MGC4175 9.3
3-ketoacyl-CoA thiolase, mitochondrial 9.3
Forkhead box L1 9.3
UBXN2A protein 9.3
nin one binding protein 9.3
Vanin-2 9.3
ZNF343 9.3
MMS19L 9.1
Receptor tyrosine kinase-like orphan receptor 2 9.1
LCRMP 8.9
SH3GL1 8.9
KRTCAP3 8.9
PRSM1 8.9
TTC19 protein 8.9
PR domain containing 1, with ZNF domain 8.9
NY-CO-8 8.9
LMNA protein 8.9
receptor (TNFRSF)-interacting serine-threonine kinase 1 8.9
interferon-induced protein 44-like 8.9
FBXO39 8.9
transcription factor E2F6 8.9
more...
Disease
osteosarcoma 10.9
Osteosarcoma 10.9
Intracortical osteosarcoma 10.9
Osteosarcoma 10.9
Chest wall mass 10.9
Parosteal osteosarcoma 10.8
Aggressive osteoblastoma 10.7
Periosteal osteosarcoma 10.7
metastatic osteosarcoma 10.5
Extraskeletal osteosarcoma 10.4
recurrent osteosarcoma 10.4
fibroblastic osteosarcoma 10.3
anaplastic osteosarcoma 10.3
localized osteosarcoma 10.2
chondroblastic osteosarcoma 10.1
Small cell osteosarcoma 10.1
telangiectatic osteosarcoma 10.0
Giant cell sarcoma 9.9
musculoskeletal cancer 9.9
Osteosarcoma of bone 9.9
Carcinomatous pleurisy 9.9
HOS 9.6
Fibro-osseous pseudotumor 9.6
malignant fibrous histiocytoma of bone 9.5
osteoblastic osteosarcoma 9.5
Malignant mesenchymoma 9.4
mixed osteosarcoma 9.3
Staphylococcal osteomyelitis 9.3
bone cancer 9.2
connective tissue cancer 9.0
Bone sarcomas 9.0
Well-differentiated squamous cell carcinoma 8.9
Ameloblastic fibro-odontosarcoma 8.9
malignant giant cell tumor of bone 8.9
bone neoplasm 8.8
Osteoblastoma 8.6
arthritis deformans 8.6
Hodgkin's granuloma 8.6
dermoid inclusion 8.6
Periosteal chondrosarcoma 8.4
Myositis ossificans circumscripta 8.4
mesenchymoma 8.4
Ewing's sarcoma 8.4
Cardiac neoplasms 8.3
Malignant giant cell tumor 8.3
Endocardiosis 8.3
Dedifferentiated chordoma 8.3
chondrosarcoma 8.3
OHS 8.2
Cemento-osseous dysplasia 8.2
Clear cell chondrosarcoma 8.1
chondroblastoma 8.1
Soft Tissue Tumor 7.9
myxosarcoma 7.8
recurrent skin cancer 7.7
Skin flap necrosis 7.7
carcinoma of the ear 7.7
Myositis ossificans 7.6
Malignant Peripheral Nerve Sheath Tumor 7.6
malignant fibrous histiocytoma 7.6
Chondrosarcoma 7.5
Chondrosarcoma 7.5
Malignant chondroid syringoma 7.4
Bilateral hearing loss 7.4
Renal metastasis 7.4
osteochondroma 7.3
Oropharyngeal mucositis 7.3
skeletal neoplasm 7.3
Osteopathia striata 7.2
Pediatric Tumor 7.2
adult soft tissue sarcoma 7.2
Sarcoma 7.1
Sarcoma 7.1
Condensing osteitis 7.1
musculoskeletal neoplasm 7.1
mucinous adenocarcinoma of the rectum 7.1
nasopharyngeal neoplasm 7.1
hemangiosarcoma 7.1
neurofibrosarcoma 7.1
Dedifferentiated chondrosarcoma 7.0
more...
Symptom
lipuria 8.1
Chills and fever 7.6
Localized pain 6.2
sinus congestion 5.6
Flu-like symptoms 5.1
Severe diarrhea 5.1
eye discharge 4.8
skin pain 4.7
growing pains 4.3
Scratch 4.3
bone pain 4.1
Visual disturbances 4.1
heel pain 4.0
stump pain 4.0
leg cramps 3.7
exertional chest pain 3.6
limb pain 3.5
jaw pain 3.4
knee pain 3.4
Opposition 3.2
pedal edema 3.2
dyschezia 3.1
thigh pain 3.1
cancer pain 2.9
hip pain 2.9
nipple discharge 2.9
flank pain 2.8
nipple discharge 2.8
adenitis 2.8
No adverse effect 2.6
nausea and vomiting 2.5
distraction 2.5
hoarseness 2.4
productive cough 2.3
irregular bleeding 2.3
intestinal bleeding 2.2
tingling 2.2
clubbing 2.1
Spots 2.1
orthopnea 2.1
paraparesis 2.1
lethargy 2.0
tenesmus 2.0
HSA 1.9
arm pain 1.9
syncopal episodes 1.9
leg pain 1.9
numbness 1.9
sciatica 1.9
ankle pain 1.8
retching 1.8
shoulder pain 1.8
abnormal gait 1.8
abdominal discomfort 1.7
Gastrointestinal symptoms 1.7
decreased appetite 1.7
dental pain 1.7
neck stiffness 1.7
cachexia 1.6
nasal discharge 1.5
clonus 1.4
vomiting 1.3
groin pain 1.3
chest tightness 1.3
pain 1.3
neck pain 1.3
dysuria 1.2
rigors 1.2
consciousness disturbance 1.2
paresthesia 1.2
wrist pain 1.2
starvation 1.2
thinning 1.1
nausea 1.1
dyspnea 1.1
cyanosis 1.0
orofacial pain 1.0
chest pain 1.0
paresis 1.0
Stiffness 0.9
more...
Drug
Mifamurtide 10.4
Quadramet 8.8
Molgramostim 8.3
7-Hydroxystaurosporine 7.7
Proflavin 7.6
Gluthathione 7.2
Formycin 7.1
Fenobam 6.9
2-Methoxyestradiol 6.5
L-Homoarginine 6.3
Sparsomycin 6.2
Risedronate sodium 6.1
Vindesine 6.0
Vindesine 6.0
Pirarubicin 6.0
Pralatrexate 5.9
Cyclandelate 5.9
Interferon beta-1a 5.9
Teriparatide 5.8
Zebularine 5.8
Calcium silicate 5.7
PTH 5.6
Gallium nitrate 5.6
Adriamycin 5.5
Olomoucine 5.4
Panorex 5.4
Aredia 5.3
ROS 5.3
Zoledronic acid 5.2
Compound 16 5.2
Denosumab 5.1
Barium sulfate 5.1
CMX 5.1
Parecoxib 5.1
Hydroxypropyl cellulose 5.1
Zoledronic acid 5.0
Leucovorin 4.9
VCR 4.8
Dodecyl Sulfate 4.8
Cilengitide 4.7
Trabectedin 4.7
Vitamin K2 4.7
GEO 4.5
ADM 4.5
Auranofin 4.5
Dexrazoxane 4.5
Pyridostigmine bromide 4.4
PDGF B-chain 4.4
MINO 4.4
Salmon calcitonin 4.4
Valproic Acid 4.4
Insulin glargine 4.3
Ferumoxytol 4.3
Sodium thiosulfate 4.3
Glybenclamide 4.3
Quinine, 4.2
Flavopiridol 4.2
Diamminedichloroplatinum 4.2
Arsenic trioxide 4.0
CDP 4.0
NVP 4.0
EHDP 3.9
Etoposide 3.9
Ipriflavone 3.9
Clodronate 3.9
BLM 3.8
ADR 3.8
MDM 3.8
Dihydrotestosterone 3.8
Vioxx 3.8
Pyridoxal phosphate 3.8
Bestatin 3.7
Human Serum Albumin 3.7
Ibandronate 3.7
Aprepitant 3.6
VCR 3.6
IL-11 3.6
Calcipotriol 3.6
PDL 3.5
3-Methyladenine 3.5
more...
Enzyme
Dm-dNK 7.3
meprin B 7.0
collagen galactosyltransferase 6.5
bothropasin 6.1
NAD+ kinase 5.5
carboxypeptidase G2 5.4
phosphatidylinositol phospholipase C 5.3
IOR 5.3
cystathionine beta-lyase 5.2
IMP dehydrogenase 5.1
cathepsin F 4.9
MHCK 4.8
MDP 4.7
inositol 3-kinase 4.6
alkaline phosphatase 4.6
endoglycoceramidase 4.6
luciferase 4.5
heparitinase I 4.5
caspase-9 4.4
matrix metalloproteinase 9 4.4
nicotinamide N-methyltransferase 4.3
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.3
procollagen C-proteinase 4.2
caspase-8 4.2
transcarboxylase 4.1
acetylserotonin O-methyltransferase 4.1
GalNAc-T 4.1
caspase-3 4.1
PARP 4.1
caspase-6 4.0
amidophosphoribosyltransferase 4.0
caspase-6 3.9
nicotinamide mononucleotide adenylyltransferase 3.9
thymidine kinase 3.9
tripeptidase 3.9
stromelysin-3 3.9
interstitial collagenase 3.8
matrix metalloproteinase 2 3.8
adenylate cyclase 3.8
cathepsin K 3.7
7-dehydrocholesterol reductase 3.7
P-glycoprotein 3.7
deoxyguanosine kinase 3.7
cathepsin X 3.7
glycinamide ribonucleotide transformylase 3.7
caspase-2 3.6
fatty-acid synthase 3.6
glucosylceramide synthase 3.6
dihydrofolate reductase 3.6
caspase-2 3.6
cdc2 3.6
VIP1 3.5
polo-like kinase 1 3.5
type III procollagen 3.5
folylpolyglutamate synthetase 3.5
GSK 3.4
chondroitin ABC lyase 3.4
caspase-4 3.4
KLK7 3.4
chloramphenicol acetyltransferase 3.4
p80 3.4
MMP 3.4
GD3 synthase 3.4
histone demethylase 3.3
PI-PLC 3.3
urokinase-type plasminogen activator 3.2
17beta-HSD 3.2
dUTPase 3.2
HCS 3.2
caspase-4 3.2
poly(ADP-ribose) glycohydrolase 3.2
CPM 3.1
prolyl hydroxylase 3.1
MMP-3 3.1
lactic acid dehydrogenase 3.1
2A protease 3.1
branched-chain aminotransferase 3.1
methylthioadenosine phosphorylase 3.0
deoxycytidine kinase 3.0
lactic acid dehydrogenase 3.0
more...
Compound
9-ethyl-9H-purine 10.9
butyl thiocyanate 10.9
2-Amino-5-nitrophenol 9.9
9,10-Anthracenedicarboxaldehyde 9.9
AD-143 9.9
Voacamine 9.3
NSC 337766 9.3
Sennoside B 9.3
Oleoyl lysophosphatidic acid 9.3
TMTS 9.3
2-methyloctanoic acid 8.9
[1,2,4]triazolo[4,3-a]pyrimidine 8.6
Radium-224 8.6
Daphnoretin 8.3
Raddeanin A 8.2
K-DR 8.1
MNNG 8.1
Chimaphilin 7.9
3-azaspiro[5.5]undecane 7.9
4(1H)-quinolinone 7.9
Capillarisin 7.9
Acronycine 7.7
Aspidin 7.6
Tomentosin 7.6
Poncirin 7.6
Boc-glycine 7.6
Clomesone 7.6
Euxanthone 7.4
Bruceine D 7.3
Indicine N-oxide 7.2
Aloperine 7.2
Mitozolomide 7.2
Tricetin 7.2
Aloesin 7.1
Pachymic acid 7.1
Picropodophyllin 7.1
PRPP 7.0
Calycosin 7.0
Cinobufagin 6.9
2-sulfobenzoic acid 6.9
5-chloro-7-iodo-8-quinolinol 6.8
Flavone acetic acid 6.8
2-Acetylpyridine 6.7
Ifosfamide 6.7
Ara-T 6.7
Chebulinic acid 6.6
1-methyl-1H-pyrrole 6.6
2-Methoxyestradiol 6.5
2-Aminofluorene 6.5
Lauryl gallate 6.5
beta-Ionone 6.5
Bufalin 6.4
Fraxetin 6.4
Sennoside A 6.4
Diamminedichloroplatinum 6.4
Tomatidine 6.3
4-Hydroperoxycyclophosphamide 6.3
Tomatidine 6.3
alpha-Estradiol 6.2
Sparsomycin 6.2
11-aminoundecanoic acid 6.2
MTX 6.2
beta-Ionone 6.1
Isoalantolactone 6.0
HPTE 5.9
AD 32 5.9
N6-Methyladenosine 5.9
Fangchinoline 5.9
Janus Green B 5.9
Tectorigenin 5.9
Carnosol 5.9
1H-indole-2-carboxylic acid 5.9
Physcion 5.9
Lycorine 5.8
CLTC 5.8
1843U89 5.8
Diallyl disulfide 5.8
Simeon 5.8
Diallyl disulfide 5.8
Methotrexate 5.8
more...