Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0029463 (osteosarcoma)
16,637 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
osteosarcoma 14617
Sep 1084
Mol 969
p53 755
alkaline phosphatase 614
HOS 447
osteogenic 440
rhabdomyosarcoma 418
ROS 393
caspase-3 393
collagen 376
osteocalcin 310
Bcl-2 240
AKT 233
parathyroid hormone 225
p21 206
catenin 197
PI3K 189
PTH 174
cytokine 172
pRb 171
vimentin 154
mTOR 144
matrix metalloproteinase 138
fibronectin 137
vascular endothelial growth factor 134
adenylate cyclase 134
MRI 123
endoplasmic reticulum 121
ERK 120
ATP 118
cyclin D1 118
UTR 115
insulin 114
p38 114
MAPK 113
ERK1 112
osteopontin 111
She 111
PARP 109
MMP-9 109
annexin V 104
interferon 104
MMP-2 103
caspase-9 100
MDM2 99
histone 95
P-glycoprotein 93
E-cadherin 88
tumor necrosis factor 87
IL-6 85
cytochrome c 84
kit 82
insulin-like growth factor 82
MTX 82
type I collagen 81
CCK 80
JNK 80
VEGF 79
bone morphogenetic protein 79
glycoprotein 78
STAT3 77
NMR 76
c-fos 76
caspase-8 74
epidermal growth factor 73
fused 72
Fas 72
MMP9 71
proliferating cell nuclear antigen 69
TNF 67
parathyroid hormone-related protein 66
tyrosine kinase 66
vitamin D receptor 66
RUNX2 65
AS1 65
c-myc 65
osteonectin 65
c-Myc 64
cyclin 63
more...
Disease
osteosarcoma 16637
tumor 6675
cancer 5588
Osteosarcoma 2200
Osteosarcoma 2200
metastases 1656
sarcoma 1190
Ewing's sarcoma 830
chondrosarcoma 701
tumor growth 699
carcinoma 613
tumorigenesis 560
HOS 448
primary tumor 426
rhabdomyosarcoma 414
breast cancer 388
melanoma 385
fibrosarcoma 362
leukemia 340
tumor progression 337
bone cancer 327
lung metastases 316
retinoblastoma 307
neuroblastoma 290
lymphoma 260
metastatic osteosarcoma 258
adenocarcinoma 258
malignant fibrous histiocytoma 257
carcinogenesis 212
dysplasia 197
hepatocellular carcinoma 187
WT1 158
liposarcoma 156
leiomyosarcoma 154
Hodgkin's disease 148
lung cancer 147
squamous cell carcinoma 144
prostate cancer 143
osteoporosis 142
Sarcoma 138
Sarcoma 138
synovial sarcoma 131
multiple myeloma 130
angiosarcoma 124
glioma 119
PDB 118
osteochondroma 107
osteoma 106
fibroma 106
bone metastases 94
pathological fracture 94
aggressiveness 90
childhood cancer 89
MCF 86
colon cancer 85
renal cell carcinoma 85
acute lymphoblastic leukemia 83
osteoblastic osteosarcoma 80
chordoma 79
chondroblastoma 78
myositis 78
carcinosarcoma 76
lung carcinoma 74
ovarian cancer 71
Extraskeletal osteosarcoma 70
gastric cancer 69
acute myeloid leukemia 68
DDP 68
colorectal cancer 66
glioblastoma 65
AS1 65
solid tumor 64
osteomyelitis 63
chondroblastic osteosarcoma 63
SDS 59
non-Hodgkin's lymphoma 58
myelosuppression 57
epiphysis 55
cervical cancer 55
bone disease 54
more...
Symptom
pain 337
vomiting 42
dyspnea 31
starvation 29
nausea and vomiting 28
bone pain 28
nausea 27
distraction 27
headache 23
anesthesia 23
abdominal pain 22
weakness 21
seizures 21
collapse 19
diarrhea 18
chest pain 18
knee pain 15
analgesia 13
anorexia 13
thinning 13
cough 13
lethargy 12
cancer pain 12
back pain 11
fatigue 10
numbness 10
cachexia 9
low back pain 9
ataxia 8
flank pain 8
discomfort 8
discomfort 8
hoarseness 8
respiratory distress 7
exhaustion 7
syncope 7
hip pain 7
functional recovery 7
HSA 6
paresis 6
paresthesia 6
agitation 6
paraparesis 6
neck pain 5
shoulder pain 5
arthralgia 5
acidity 5
erythema 4
Ill 4
heel pain 4
sleepiness 4
Scratch 4
limb pain 4
dizziness 4
shortness of breath 4
leg pain 4
regurgitation 4
cyanosis 4
myalgia 4
hemoptysis 4
tingling 3
dysuria 3
sciatica 3
chills 3
ENT 3
thigh pain 3
abdominal discomfort 3
hypothermia 3
productive cough 3
tremor 3
abnormal gait 2
vertigo 2
acute pain 2
dysarthria 2
polydipsia 2
rhinorrhea 2
acute abdomen 2
intestinal bleeding 2
nipple discharge 2
spasm 2
more...
Drug
ROS 393
PTH 174
Adriamycin 111
Monit 62
lysine 59
Cardiovasc 43
ADM 38
caffeine 28
CSF 25
IL-2 24
Gel 22
Dermatol 21
CDP 20
CTX 20
GEO 19
ascorbate 19
IFN-gamma 17
ADR 15
ROC 14
Retinoic acid 14
G-CSF 13
Zoledronic acid 13
Taxol 12
MAP 12
ABC 11
IFN-beta 11
Arsenic trioxide 11
ICI 11
Forskolin 11
VCR 10
DNase I 10
Zoledronic acid 10
TiO2 10
BLM 10
Teriparatide 10
Denosumab 10
CAM 10
uPA 10
Indomethacin 9
Etoposide 9
VCR 9
NVP 8
Leucovorin 8
2-Methoxyestradiol 8
EE2 8
Mifamurtide 7
SiO2 7
vitamin E 7
NADH 7
Leaf 7
IL-11 7
G418 7
Gelatin 7
RFP 6
Growth hormone 6
CTX 6
CTX 6
Mutagen 6
Fluorescein 6
CoCl2 6
CoCl2 6
Growth hormone 6
ETS 6
ZnO 6
citric acid 5
Estrogens 5
Paraffin 5
Gleevec 4
CaCl2 4
Fluorescein 4
EHDP 4
Ethanol 4
Irinotecan 4
Vitamin A 4
CCL 4
Vindesine 4
Sorafenib 4
DEX 4
Auranofin 4
Doxycycline 4
more...
Enzyme
alkaline phosphatase 616
luciferase 460
mitogen-activated protein kinase 348
caspase-3 318
ERK 312
protein kinase 230
focal adhesion kinase 158
adenylate cyclase 136
PARP 118
protein kinase C 108
P-glycoprotein 93
caspase-9 84
reverse transcriptase 75
phospholipase C 73
MEK 70
caspase-8 65
collagenase 61
thymidine kinase 59
urokinase-type plasminogen activator 53
proteasome 52
ATPase 52
cdc2 51
lactate dehydrogenase 50
ACS 45
topoisomerase 41
phosphatidylinositol 3-kinase 41
GSK 38
AMPK 38
topoisomerase 38
MDP 37
RNA polymerase 37
dihydrofolate reductase 36
AMP-activated protein kinase 31
catalase 28
acid phosphatase 28
chloramphenicol acetyltransferase 28
glutathione S-transferase 26
peroxidase 26
phosphoinositide 3-kinase 24
matrix metalloproteinase 9 24
trypsin 23
MMP 23
AMPK 23
thrombin 20
complex I 19
superoxide dismutase 18
RNase 17
calcineurin 17
matrix metalloproteinase 2 17
IMP dehydrogenase 16
APC 16
RNase 16
thymidylate synthase 15
beta-galactosidase 15
MMP-3 15
endonuclease 15
alanine aminotransferase 14
glyceraldehyde-3-phosphate dehydrogenase 14
hyaluronidase 13
phosphodiesterase 13
neuraminidase 13
cathepsin K 13
transcriptase 13
CD10 12
IKK 12
ATP synthase 11
creatine kinase 11
DNA polymerase 11
plasmin 11
aldehyde dehydrogenase 10
glyceraldehyde-3-phosphate dehydrogenase 10
glyceraldehyde-3-phosphate dehydrogenase 10
aldehyde dehydrogenase 10
glyceraldehyde-3-phosphate dehydrogenase 10
aldehyde dehydrogenase 10
aldehyde dehydrogenase 10
aldehyde dehydrogenase 10
glyceraldehyde-3-phosphate dehydrogenase 10
lysozyme 10
hyaluronidase 10
more...
Compound
DNA 1350
Dec 1085
Clin 981
calcium 470
MTT 440
oxygen 288
phosphate 237
Adriamycin 175
cAMP 163
water 146
Methotrexate 144
sodium 143
vitamin D 129
ATP 118
bromide 115
DDP 113
tyrosine 113
acetate 102
MNNG 99
titanium 98
methionine 93
glucose 93
arginine 86
ADR 85
retinoic acid 83
iodine 82
MTX 82
sulfate 81
lysine 79
serine 71
TNF 67
cysteine 65
AMP 64
NH2 62
SDS 60
iron 60
zinc 60
nitrogen 58
ALP 55
His 55
MDA 53
hydrogen 51
PEG 50
leucine 47
MEK 47
threonine 47
ACS 45
ACS 45
Asp 43
galactose 43
ADP 40
salt 40
PEG 40
Insulin 40
alanine 39
TNM 39
silver 38
ADP 36
ADP 36
cobalt 35
PGE2 35
COS 35
GSH 34
proline 34
GSH 34
Gly 34
ethanol 33
creatinine 33
GTP 33
Phe 32
acridine 32
urea 30
phosphorus 30
nitric oxide 30
Vimentin 30
Dexamethasone 30
copper 30
25-dihydroxycholecalciferol 30
dUTP 29
N-acetylcysteine 29
more...