Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
osteosarcoma 14617
Sep 1084
Mol 969
p53 755
alkaline phosphatase 614
HOS 447
osteogenic 440
rhabdomyosarcoma 418
ROS 393
caspase-3 393
collagen 376
osteocalcin 310
Bcl-2 240
AKT 233
parathyroid hormone 225
p21 206
catenin 197
PI3K 189
PTH 174
cytokine 172
pRb 171
vimentin 154
mTOR 144
matrix metalloproteinase 138
fibronectin 137
vascular endothelial growth factor 134
adenylate cyclase 134
MRI 123
endoplasmic reticulum 121
ERK 120
ATP 118
cyclin D1 118
UTR 115
insulin 114
p38 114
MAPK 113
ERK1 112
osteopontin 111
She 111
MMP-9 109
PARP 109
annexin V 104
interferon 104
MMP-2 103
caspase-9 100
MDM2 99
histone 95
P-glycoprotein 93
E-cadherin 88
tumor necrosis factor 87
IL-6 85
cytochrome c 84
insulin-like growth factor 82
MTX 82
kit 82
type I collagen 81
JNK 80
CCK 80
bone morphogenetic protein 79
VEGF 79
glycoprotein 78
STAT3 77
NMR 76
c-fos 76
caspase-8 74
epidermal growth factor 73
fused 72
Fas 72
MMP9 71
proliferating cell nuclear antigen 69
TNF 67
vitamin D receptor 66
tyrosine kinase 66
parathyroid hormone-related protein 66
c-myc 65
AS1 65
osteonectin 65
RUNX2 65
c-Myc 64
estrogen receptor 63
cyclin 63
beta 1 61
CXCR4 61
epidermal growth factor receptor 61
polypeptide 61
colon carcinoma 60
RB1 60
thymidine kinase 59
CDK4 58
chemokine 58
SDS 58
AMP 57
Ki-67 57
TGF-beta 57
calcitonin 56
p27 55
RANKL 55
ALP 55
ezrin 54
IGF-I 54
interleukin-6 54
c-Jun 54
cytokeratin 53
Alkaline phosphatase 53
survivin 53
Osteocalcin 53
proteasome 52
non-Hodgkin's lymphoma 51
AP-1 51
CD44 51
proteoglycan 49
scratch 49
platelet-derived growth factor 49
Rho 49
p65 49
p16 49
cyclin E 48
IL-8 48
osteoprotegerin 48
proto-oncogene 48
extracellular signal-regulated kinase 48
MEK 48
lymphoid 48
BMP-2 47
Li-Fraumeni syndrome 46
Ezrin 46
ras 46
desmin 46
N-cadherin 46
serum albumin 45
ACS 45
PTEN 45
cage 45
glucocorticoid receptor 44
IFN 44
CD4 44
phosphatase 43
CD133 43
CD8 43
mutant p53 43
tumour suppressor 42
CD34 42
ubiquitin 42
FDG 41
phosphatidylinositol 3-kinase 41
histone deacetylase 41
ATPase 41
DDP 41
protein kinase B 40
vitronectin 40
bone sialoprotein 40
lactate dehydrogenase 40
TNM 39
MDR1 39
urokinase-type plasminogen activator 39
Pol 38
Parathyroid hormone 38
collagenase 38
IGF-II 37
RANK 37
more...
Disease
osteosarcoma 16637
tumor 6675
cancer 5588
Osteosarcoma 2200
Osteosarcoma 2200
metastases 1656
sarcoma 1190
Ewing's sarcoma 830
chondrosarcoma 701
tumor growth 699
carcinoma 613
tumorigenesis 560
HOS 448
primary tumor 426
rhabdomyosarcoma 414
breast cancer 388
melanoma 385
fibrosarcoma 362
leukemia 340
tumor progression 337
bone cancer 327
lung metastases 316
retinoblastoma 307
neuroblastoma 290
lymphoma 260
metastatic osteosarcoma 258
adenocarcinoma 258
malignant fibrous histiocytoma 257
carcinogenesis 212
dysplasia 197
hepatocellular carcinoma 187
WT1 158
liposarcoma 156
leiomyosarcoma 154
Hodgkin's disease 148
lung cancer 147
squamous cell carcinoma 144
prostate cancer 143
osteoporosis 142
Sarcoma 138
Sarcoma 138
synovial sarcoma 131
multiple myeloma 130
angiosarcoma 124
glioma 119
PDB 118
osteochondroma 107
osteoma 106
fibroma 106
pathological fracture 94
bone metastases 94
aggressiveness 90
childhood cancer 89
MCF 86
renal cell carcinoma 85
colon cancer 85
acute lymphoblastic leukemia 83
osteoblastic osteosarcoma 80
chordoma 79
myositis 78
chondroblastoma 78
carcinosarcoma 76
lung carcinoma 74
ovarian cancer 71
Extraskeletal osteosarcoma 70
gastric cancer 69
DDP 68
acute myeloid leukemia 68
colorectal cancer 66
glioblastoma 65
AS1 65
solid tumor 64
osteomyelitis 63
chondroblastic osteosarcoma 63
SDS 59
non-Hodgkin's lymphoma 58
myelosuppression 57
cervical cancer 55
epiphysis 55
bone disease 54
bone neoplasm 53
herpes simplex 51
B-cell lymphoma 51
chondroma 51
aggression 51
RTS 50
pancreatic cancer 49
Li-Fraumeni syndrome 49
primitive neuroectodermal tumor 48
primitive neuroectodermal tumor 47
SEM 47
HIV 47
non-small cell lung cancer 46
telangiectatic osteosarcoma 46
arthrodesis 46
periosteum 46
hypercalcemia 46
hepatoblastoma 45
mesenchymoma 44
medulloblastoma 43
SCID 42
Chondrosarcoma 42
Chondrosarcoma 42
bladder cancer 41
mesothelioma 41
Osteoblastoma 40
epithelial ovarian cancer 39
tumor angiogenesis 39
diabetes 39
osteoarthritis 39
Parosteal osteosarcoma 38
hemangiosarcoma 37
rare disease 37
anemia 36
hemangioma 36
Blocking 36
plasmacytoma 35
EMT 35
residual disease 35
adenoma 34
ameloblastoma 34
meningioma 33
GSH 33
histiocytic lymphoma 33
thrombocytopenia 32
liver cancer 32
infectious diseases 32
schwannoma 32
localized osteosarcoma 32
desmoid 31
immunodeficiency 31
periostitis 31
neutropenia 31
brain tumor 31
recurrent osteosarcoma 31
teratoma 31
cold 30
arthritis 30
liver cancer 29
uterus 29
astrocytoma 29
pneumothorax 29
fibroblastic osteosarcoma 29
lipoma 29
hemangiopericytoma 29
Bone sarcomas 29
thyroid cancer 29
pertussis 29
tumor initiation 28
sepsis 28
MTS 27
rheumatoid arthritis 27
Burkitt's lymphoma 26
enchondroma 26
acute leukemia 26
TEM 25
neoplastic transformation 25
heart failure 25
renal cancer 24
TEM 24
more...
Symptom
pain 337
vomiting 42
dyspnea 31
starvation 29
nausea and vomiting 28
bone pain 28
nausea 27
distraction 27
headache 23
anesthesia 23
abdominal pain 22
weakness 21
seizures 21
collapse 19
chest pain 18
diarrhea 18
knee pain 15
anorexia 13
analgesia 13
cough 13
thinning 13
cancer pain 12
lethargy 12
back pain 11
fatigue 10
numbness 10
cachexia 9
low back pain 9
hoarseness 8
discomfort 8
flank pain 8
ataxia 8
discomfort 8
functional recovery 7
respiratory distress 7
exhaustion 7
syncope 7
hip pain 7
paresis 6
paresthesia 6
paraparesis 6
agitation 6
HSA 6
shoulder pain 5
arthralgia 5
acidity 5
neck pain 5
sleepiness 4
leg pain 4
Scratch 4
erythema 4
myalgia 4
limb pain 4
dizziness 4
regurgitation 4
Ill 4
shortness of breath 4
cyanosis 4
heel pain 4
hemoptysis 4
sciatica 3
abdominal discomfort 3
thigh pain 3
hypothermia 3
dysuria 3
chills 3
ENT 3
tingling 3
productive cough 3
tremor 3
nipple discharge 2
hepatosplenomegaly 2
decreased appetite 2
polydipsia 2
epigastric pain 2
apathy 2
acute abdomen 2
tense 2
nasal discharge 2
constipation 2
nipple discharge 2
spasm 2
clubbing 2
vertigo 2
adenitis 2
overweight 2
splenomegaly 2
rhinorrhea 2
intestinal bleeding 2
dysarthria 2
pallor 2
tinnitus 2
acute pain 2
dental pain 2
abnormal gait 2
tachypnea 2
hepatomegaly 1
chest tightness 1
consciousness disturbance 1
hyperoxia 1
neck stiffness 1
hypercapnia 1
orofacial pain 1
blepharospasm 1
Sedation 1
lipuria 1
hot flushes 1
jaw pain 1
urinary frequency 1
dry skin 1
leg cramps 1
irregular bleeding 1
sinus congestion 1
cerebellar ataxia 1
colic 1
ophthalmoplegia 1
menopausal symptoms 1
Localized pain 1
Visual disturbances 1
orthopnea 1
pedal edema 1
retching 1
groin pain 1
Gastrointestinal symptoms 1
No adverse effect 1
clonus 1
neuralgia 1
ankle pain 1
tenesmus 1
rigors 1
arm pain 1
chronic cough 1
Postoperative pain 1
exertional dyspnea 1
Stiffness 1
oliguria 1
stridor 1
wrist pain 1
acute stress 1
bitter taste 1
syncopal episodes 1
stump pain 1
eye discharge 1
facial pain 1
memory loss 1
Chills and fever 1
Flu-like symptoms 1
pelvic pain 1
torticollis 1
Spots 1
Severe diarrhea 1
Opposition 1
dyschezia 1
skin pain 1
growing pains 1
Neuropathic pain 1
polyuria 1
asthenia 1
exertional chest pain 1
Drug
ROS 393
PTH 174
Adriamycin 111
Monit 62
lysine 59
Cardiovasc 43
ADM 38
caffeine 28
CSF 25
IL-2 24
Gel 22
Dermatol 21
CTX 20
CDP 20
ascorbate 19
GEO 19
IFN-gamma 17
ADR 15
ROC 14
Retinoic acid 14
Zoledronic acid 13
G-CSF 13
Taxol 12
MAP 12
ABC 11
ICI 11
Forskolin 11
IFN-beta 11
Arsenic trioxide 11
DNase I 10
BLM 10
TiO2 10
Teriparatide 10
Denosumab 10
uPA 10
CAM 10
VCR 10
Zoledronic acid 10
Etoposide 9
VCR 9
Indomethacin 9
NVP 8
Leucovorin 8
2-Methoxyestradiol 8
EE2 8
G418 7
vitamin E 7
Gelatin 7
SiO2 7
Leaf 7
IL-11 7
Mifamurtide 7
NADH 7
CTX 6
CoCl2 6
ZnO 6
CoCl2 6
Mutagen 6
CTX 6
Fluorescein 6
Growth hormone 6
RFP 6
ETS 6
Growth hormone 6
Paraffin 5
citric acid 5
Estrogens 5
Vindesine 4
DEX 4
Irinotecan 4
Auranofin 4
Gleevec 4
Vindesine 4
CaCl2 4
CaCl2 4
Asn 4
EHDP 4
PDL 4
DMSA 4
MRC 4
Fluorescein 4
Doxycycline 4
Imatinib 4
Docetaxel 4
Sorafenib 4
CCL 4
Ethanol 4
CaCl2 4
Vitamin A 4
AZT 3
Ketoconazole 3
Gelfoam 3
MDM 3
Alanine 3
ENT 3
ZnCl2 3
ACT 3
Activin 3
CPM 3
Quadramet 3
ALA 3
Dihydrotestosterone 3
Aloe 3
MDS 3
AZT 3
Fragment 3
p75 3
CPT-11 3
Spectrum 3
ETA 3
-deoxyadenosine 3
Simvastatin 3
Pirarubicin 3
CTC 3
ZnCl2 3
Urokinase 2
Salmon calcitonin 2
Gallium nitrate 2
Kenyan 2
Herceptin 2
TAC 2
CED 2
Monensin 2
Zebularine 2
Fraction 2
Hyaluronidase 2
Diamminedichloroplatinum 2
TTC 2
Flavopiridol 2
Bestatin 2
Vitamin K2 2
Raloxifene 2
Everolimus 2
Ouabain 2
Biopolymers 2
PDGF B-chain 2
CMX 2
THF 2
Taxotere 2
Meth 2
nitroglycerin 2
Pemetrexed 2
Compound 16 2
PTC 2
Dexrazoxane 2
Ringer's solution 2
NBT 2
Calcium silicate 2
TEL 2
Hyaluronidase 2
Silica 2
Trabectedin 2
Clodronate 2
ampicillin 2
APD 2
HCG 2
Gefitinib 2
IPM 2
PCB 2
Myricetin 1
more...
Enzyme
alkaline phosphatase 616
luciferase 460
mitogen-activated protein kinase 348
caspase-3 318
ERK 312
protein kinase 230
focal adhesion kinase 158
adenylate cyclase 136
PARP 118
protein kinase C 108
P-glycoprotein 93
caspase-9 84
reverse transcriptase 75
phospholipase C 73
MEK 70
caspase-8 65
collagenase 61
thymidine kinase 59
urokinase-type plasminogen activator 53
ATPase 52
proteasome 52
cdc2 51
lactate dehydrogenase 50
ACS 45
topoisomerase 41
phosphatidylinositol 3-kinase 41
AMPK 38
topoisomerase 38
GSK 38
MDP 37
RNA polymerase 37
dihydrofolate reductase 36
AMP-activated protein kinase 31
catalase 28
acid phosphatase 28
chloramphenicol acetyltransferase 28
glutathione S-transferase 26
peroxidase 26
phosphoinositide 3-kinase 24
matrix metalloproteinase 9 24
AMPK 23
trypsin 23
MMP 23
thrombin 20
complex I 19
superoxide dismutase 18
calcineurin 17
RNase 17
matrix metalloproteinase 2 17
APC 16
IMP dehydrogenase 16
RNase 16
thymidylate synthase 15
endonuclease 15
MMP-3 15
beta-galactosidase 15
alanine aminotransferase 14
glyceraldehyde-3-phosphate dehydrogenase 14
transcriptase 13
cathepsin K 13
hyaluronidase 13
neuraminidase 13
phosphodiesterase 13
CD10 12
IKK 12
plasmin 11
DNA polymerase 11
ATP synthase 11
creatine kinase 11
glyceraldehyde-3-phosphate dehydrogenase 10
glyceraldehyde-3-phosphate dehydrogenase 10
glyceraldehyde-3-phosphate dehydrogenase 10
hyaluronidase 10
aldehyde dehydrogenase 10
aldehyde dehydrogenase 10
lysozyme 10
glyceraldehyde-3-phosphate dehydrogenase 10
aldehyde dehydrogenase 10
aldehyde dehydrogenase 10
aldehyde dehydrogenase 10
tissue plasminogen activator 9
HSD 9
cathepsin B 9
MAP 9
DNA methyltransferase 9
phospholipase A2 9
polo-like kinase 1 9
prolyl hydroxylase 8
aspartate aminotransferase 8
MDR 8
DNase 8
transglutaminase 7
granzyme B 7
caspase-1 7
interstitial collagenase 7
glutathione peroxidase 7
asparaginase 7
NOS 7
lipoxygenase 7
PDK1 7
protein phosphatase 2A 7
prostate-specific antigen 6
ornithine decarboxylase 6
Dm-dNK 6
ribonuclease 6
succinate dehydrogenase 6
MEKK1 6
ribonuclease 6
cathepsin D 5
Alternating 5
caspase-2 5
11beta-hydroxysteroid dehydrogenase 5
kinesin 5
histone demethylase 5
cathepsin L 5
beta-glucuronidase 5
caspase-2 5
chymotrypsin 5
5'-nucleotidase 5
aequorin 5
type III procollagen 4
glutathione reductase 4
isocitrate dehydrogenase 4
carbonic anhydrase 4
caspase-6 4
prostate-specific membrane antigen 4
prostaglandin synthetase 4
pepsin 4
papain 4
CD13 4
phosphoglucose isomerase 4
cytochrome oxidase 4
CAD 4
carboxypeptidase G2 4
demethylase 4
caspase-6 4
CAD 4
ribonucleotide reductase 4
pyruvate dehydrogenase 4
SPC 4
DTA 4
ribonucleotide reductase 4
tyrosine hydroxylase 4
CAD 4
firefly luciferase 4
chitinase 3
caspase-7 3
isocitrate dehydrogenase 3
deoxycytidine kinase 3
furin 3
PNGase F 3
aspartate transcarbamylase 3
p80 3
NADPH oxidase 3
ALDH 3
NADPH oxidase 3
lysyl oxidase 3
pyruvate dehydrogenase 3
TdT 3
IOR 3
more...
Compound
DNA 1350
Dec 1085
Clin 981
calcium 470
MTT 440
oxygen 288
phosphate 237
Adriamycin 175
cAMP 163
water 146
Methotrexate 144
sodium 143
vitamin D 129
ATP 118
bromide 115
DDP 113
tyrosine 113
acetate 102
MNNG 99
titanium 98
glucose 93
methionine 93
arginine 86
ADR 85
retinoic acid 83
MTX 82
iodine 82
sulfate 81
lysine 79
serine 71
TNF 67
cysteine 65
AMP 64
NH2 62
iron 60
zinc 60
SDS 60
nitrogen 58
ALP 55
His 55
MDA 53
hydrogen 51
PEG 50
leucine 47
MEK 47
threonine 47
ACS 45
ACS 45
Asp 43
galactose 43
PEG 40
salt 40
Insulin 40
ADP 40
TNM 39
alanine 39
silver 38
ADP 36
ADP 36
cobalt 35
PGE2 35
COS 35
Gly 34
proline 34
GSH 34
GSH 34
ethanol 33
creatinine 33
GTP 33
acridine 32
Phe 32
copper 30
phosphorus 30
Dexamethasone 30
Vimentin 30
urea 30
25-dihydroxycholecalciferol 30
nitric oxide 30
MTS 29
dUTP 29
N-acetylcysteine 29
caffeine 28
Collagen 28
boron 28
Ifosfamide 28
potassium 28
pyrimidine 28
pyrimidine 28
Pac 27
VP-16 27
silicon 27
selenium 26
ADP-ribose 26
fluorine 26
TEM 25
ammonium 24
glutamate 22
TCP 21
TCP 21
TCP 21
TCP 21
hydroxide 21
Mg2+ 21
CDP 20
strontium 20
PMA 20
EDTA 20
EDTA 20
nickel 20
CTX 20
Curcumin 19
tryptophan 19
Vitamin D 19
nitrate 19
carbonate 18
folinic acid 18
NAD 18
aluminum 17
ASA 17
glutamine 17
HCl 17
PDT 16
NAD 16
CAT 16
CAT 16
hyaluronic acid 16
CAT 16
PRPP 15
Hoechst 33342 15
methanol 15
vanadium 14
Estrogen 14
glycerol 14
formaldehyde 14
prostaglandin E1 14
BCG 14
TPA 14
manganese 14
PMA 14
THP 14
Estradiol 14
THP 14
TPA 14
BLM 14
Panam 13
CAM 13
Estrogen 13
guanidine 13
cadmium 13
DFS 13
acetic acid 13
uridine 13
CBDCA 13
PGE 13
CBDCA 13
Gemcitabine 12
Gemcitabine 12
Triton X-100 12
ethyl acetate 12
DEAE 12
more...