Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Osteosarcoma
(OS) is a primary malignant bone neoplasm with high frequencies of tumor metastasis and recurrence. Although the Akt/PKB signaling pathway is known to play key roles in tumorigenesis, the roles of
cyclin-dependent kinase-like 3
(
CDKL3
) in OS progression remain largely elusive. We have demonstrated the high expression levels of
CDKL3
in OS human specimens and comprehensively investigated the role of
CDKL3
in promoting OS progression both in vitro and in vivo. We found that
CDKL3
regulates Akt activation and its downstream effects, including cell growth and autophagy. The up-regulation of
CDKL3
in OS specimens appeared to be associated with Akt activation and shorter overall patient survival (
P
= 0.003). Our findings identify
CDKL3
as a critical regulator that stimulates OS progression by enhancing Akt activation.
CDKL3
represents both a biomarker for OS prognosis, and a potential therapeutic target in precision medicine by targeting
CDKL3
to treat Akt hyper-activated OS.
...
PMID:CDKL3 promotes osteosarcoma progression by activating Akt/PKB. 3223 50
