Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Osteosarcoma
is the most common primary bone malignancy; however, the molecular mechanisms of development are not well understood. Progestin and AdipoQ receptors (
PAQR3
), a protein specifically localized in the Golgi apparatus, was recently characterized as a new tumor suppressor. Little is known about the expression and function of
PAQR3
in
osteosarcoma
. Here, we showed that
PAQR3
was downregulated in
osteosarcoma
tissues compared with the adjacent normal regions in 80 paired samples. Moreover, lower levels of
PAQR3
were associated with metastasis in clinical
osteosarcoma
patients. In addition, overexpression of
PAQR3
in the
osteosarcoma
cell line MG-63 inhibited cell proliferation, migration, and invasion by promoting ERK phosphorylation. Taken together, our results indicated that
PAQR3
might act as a tumor suppressor in
osteosarcoma
, providing a novel diagnostic and therapeutic option for human
osteosarcoma
in the future.
...
PMID:The tumor suppressor role of PAQR3 in osteosarcoma. 2551 Jun 70
