Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The disabled homolog 2 interactive protein (DAB2IP) gene is a member of the family of Ras GTPases and functions as a tumor suppressor in many types of carcinoma; however, its function in
osteosarcoma
remains unclear. The aim of the present study was to determine the function of DAB2IP in
osteosarcoma
and normal bone cells
in vitro
. The expression of
DAB2IP protein
was assessed in osteoblast and
osteosarcoma
cell lines by western blot analysis. The effects of DAB2IP expression on cell proliferation, colony formation, apoptosis, cell cycle, and cell migration and invasion were evaluated by
in vitro
studies. DAB2IP expression was lower in
osteosarcoma
cell lines than in normal osteoblast cell lines. DAB2IP expression affected cell proliferation, apoptosis and cell cycle distribution. In addition, DAB2IP inhibited the migration and invasion of
osteosarcoma
and normal osteoblast cells. Therefore, DAB2IP may function as a tumor suppressor in
osteosarcoma
cell lines by inhibiting cell proliferation and invasion.
...
PMID:Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells. 2996 35
