Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
BACKGROUND
G protein-coupled receptor 110
(
GPR110
) belongs to the subfamily of the adhesion G protein-coupled receptors (GPCRs). The potential role of
GPR110
has been correlated with cancer cell invasion in some tumors such as glioma. However, its expression and role in human
osteosarcoma
has not been identified. This study aimed to examine the expression level of
GPR110
and determine whether the expression of
GPR110
was correlated with aggressive clinicopathological characteristics and prognosis of
osteosarcoma
. MATERIAL AND METHODS This retrospective study included 94
osteosarcoma
patients. Immunohistochemistry staining and quantitative real-time polymerase chain reaction were performed to detect the expression level of
GPR110
in
osteosarcoma
specimens. We then determined the correlation of the
GPR110
expression with the clinicopathological characteristics and prognosis by univariate or multivariate analysis. Patient outcomes were evaluated using the Kaplan-Meier log-rank test and prognostic factors were detected by multivariate analysis. The function of
GPR110
on cell proliferation, migration, and invasion were examined in this in vitro study. RESULTS Overexpression of
GPR110
was correlated with the advanced stage of
osteosarcoma
. Patients with high expression level of
GPR110
had significantly poorer 5-year overall survival; the multivariate analysis found that
GPR110
expression level can act as an independent prognosis factor. Knockdown of
GPR110
can decrease the proliferation, migration, and invasion capacity of human
osteosarcoma
cell lines. CONCLUSIONS Our studies suggest a role of
GPR110
in tumor progression and as a potential novel prognostic biomarker in
osteosarcoma
.
...
PMID:Clinical Significance of G Protein-Coupled Receptor 110 (GPR110) as a Novel Prognostic Biomarker in Osteosarcoma. 3005 20
