Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Death associated protein kinase (DAPK)-related apoptosis-inducing protein kinase (DRAK)-1 is a positive apoptosis regulator. However, the molecular mechanisms underlying the
DRAK1
-mediated apoptotic pathway remain unclear. In this study, we demonstrated the intracellular localization and binding partners of
DRAK1
. In human
osteosarcoma
cell line U2OS cells,
DRAK1
was mainly localized in the nucleus and translocated outside the nucleus through Ser
395
phosphorylation by protein kinase C. In the nucleus,
DRAK1
associated with tumor suppressor p53 and positively regulated p53 transcriptional activity in response to DNA-damaging agent cisplatin. On the other hand,
DRAK1
interacted with the mitochondrial inner-membrane protein, adenine nucleotide translocase (ANT)-2, an anti-apoptotic oncoprotein, outside the nucleus. These findings suggest that
DRAK1
translocates in response to stimuli and induces apoptosis through its interaction with specific binding partners, p53 and/or ANT2.
...
PMID:Intracellular localization and binding partners of death associated protein kinase-related apoptosis-inducing protein kinase 1. 2939 38
