Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It has been reported that long form collapsin response mediator protein-1 (LCRMP-1) promotes the metastasis of non-small cell lung cancer.
Osteosarcoma
(OS) is a human cancer with a high potential for metastasis. The present study aimed to investigate the role of
LCRMP
-1 in OS metastasis. The expression of
LCRMP
-1 in OS specimens and cell lines was evaluated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. Furthermore, the migration and invasion of OS cells with
LCRMP
-1-knockdown was investigated to examine the role of
LCRMP
-1 in OS metastasis. In addition, the expression of N-cadherin and matrix metalloproteinases (MMPs), which are involved in cell migration, was evaluated using RT-qPCR. Increased expression of
LCRMP
-1 was observed in the OS tissues and cell lines, accompanied by the enhanced migration and invasion of the OS cells.
LCRMP
-1-knockdown resulted in a significant decrease in the expression of N-cadherin and MMPs, as well as inhibition of the migration and invasion of the OS cells. Overexpression of
LCRMP
-1 promoted OS metastasis. Therefore,
LCRMP
-1 may be a promising target for the effective treatment of OS.
...
PMID:Long form collapsin response mediator protein-1 promotes the migration and invasion of osteosarcoma cells. 2734 94
