Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Osteosarcoma
is a common malignant bone tumor in children and adolescents under the age of 20. However, research on the pathogenesis and treatment of
osteosarcoma
is still insufficient. In the present study, based on gene-phenotype correlation network, an analysis was performed to screen disorders related to
osteosarcoma
. First, we analyzed the differential expression of
osteosarcoma
in two groups according to different types of
osteosarcoma
and screened the differentially expressed genes (DEGs) related to
osteosarcoma
. Further, these DEG coexpression modules were obtained. Finally, we identified a series of regulatory factors, such as endogenous genes, transcription factors (TFs), and ncRNAs, which have potential regulatory effects on
osteosarcoma
, based on the prediction analysis of related network of gene phenotypes. A total of 3767 DEGs of
osteosarcoma
were identified and clustered them into 20
osteosarcoma
-related dysfunction modules. And there were 38 endogenous genes (including ARF1, HSP90AB1, and
TUBA1B
), 53 TFs (including E2F1, NFKB1, and EGR1), and 858 ncRNAs (including MALAT1, miR-590-3p, and TUG1) were considered as key regulators of
osteosarcoma
through a series of function enrichment analysis and network analysis. Based on the results of the present study, we can show a new way for biologists and pharmacists to reveal the potential molecular mechanism of
osteosarcoma
typing, and provide valuable reference for different follow-up treatment options.
...
PMID:Screening of disorders associated with osteosarcoma by integrated network analysis. 3093 65
