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Symptom
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Enzyme
Compound
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Target Concepts:
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Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Magnetic resonance (MR) is currently used for diagnosis of
osteosarcoma
but not well even though contrast agents are administered. Here, we report a novel bone-targeted MR imaging contrast agent, Gd
2
-diethylenetriaminepentaacetate-bis(alendronate) (Gd
2
-
DTPA
-BA) for the diagnosis of
osteosarcoma
. It is the conjugate of a bone cell-seeking molecule (i.e., alendronate) and an MR imaging contrast agent (i.e., Gd-
DTPA
). Its physicochemical parameters were measured, including pK
a
, complex constant, and T
1
relaxivity. Its bone cell-seeking ability was evaluated by measuring its adsorption on hydroxyapatite. Hemolysis was investigated. MR imaging and biodistribution of Gd
2
-
DTPA
-BA and Gd-
DTPA
were studied on healthy and
osteosarcoma
-bearing nude mice. Gd
2
-
DTPA
-BA showed high adsorption on hydroxyapatite, the high MR relaxivity (r
1
) of 7.613mM
-1
s
-1
(2.6 folds of Gd-
DTPA
), and no hemolysis. The MR contrast effect of Gd
2
-
DTPA
-BA was much higher than that of Gd-
DTPA
after intravenous injection to the mice. More importantly, the MR imaging of
osteosarcoma
was significantly improved by Gd
2
-
DTPA
-BA. The signal intensity of Gd
2
-
DTPA
-BA reached 120.3% at 50min, equal to three folds of Gd-
DTPA
. The bone targeting index (bone/blood) of Gd
2
-
DTPA
-BA in the
osteosarcoma
-bearing mice was very high to 130 at 180min. Furthermore, the contrast enhancement could also be found in the lung due to metastasis of
osteosarcoma
. Gd
2
-
DTPA
-BA plays a promising role in the diagnoses of osteosacomas, including the primary bone tumors and metastases.
...
PMID:Magnetic resonance imaging of osteosarcoma using a bis(alendronate)-based bone-targeted contrast agent. 2768 36
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