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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Until the present time, only four cases of parosteal osteogenic sarcoma arising from the bones of the hand have been reported in the literature. The purpose of this paper is to document two new cases of parosteal osteogenic sarcoma of the hand. These tumours were localized in the proximal phalanx of the ring finger in one case and in the third metacarpal bone, in the other case. Both patients were treated by amputation of the involved metacarpo-digital ray and radiation therapy. They were free of the disease six years and eighteen months, respectively, after treatment.
Rev Chir Orthop Reparatrice Appar Mot
PMID:[Juxtacortical osteogenic sarcoma localized in the hand. Presentation of 2 cases]. 12 72

The authors have treated two hydatic cysts, three plasmocytomas, one chondrosarcoma, one osteogenic sarcoma and four metastasis at the level of the spine. The surgical procedures may be either palliative or curative. In metastatic lesions, posterior decompression was associated with internal fixation for prevention or improvement of neurological signs, providing more comfort during the patient's survival. Curative procedures were achieved a two-stages excision of the vertebra by anterior and posterior approachs, grafting and fixation using Harrington's rods. Surgery was followed by chemotherapy and roentgentherapy it should be started before onset on neurological troubles. Early results were gratifying flaccid paraplegia excluded.
Rev Chir Orthop Reparatrice Appar Mot
PMID:[Surgical technics in tumors of the spine]. 13 20

The authors describe a case of post radiation osteogenic osteosarcoma secondary to Hodgkin's disease. 14 similar cases were found in literature. They discuss the predisposition to the carcinogenesis due to the association of the chemotherapy and the radiotherapy for the treatment of Hodgkin's disease.
Rev Chir Orthop Reparatrice Appar Mot 1989
PMID:[Post-radiation osteosarcoma following Hodgkin's disease. Apropos of a case and review of the literature]. 266 Jan 99

Eight cases of human bone or soft tissue tumours were transplanted to nude mice. After such transplants to nude mice which are immunologically deficient, the malignant tumors developed like benign tumours, but maintaining malignant cytological characteristics. The transplants of normal human tissues or of benign tumours decreased in size or remained stable. The technique allowed a change of an original diagnosis of osteosarcoma to a final diagnosis of chondrosarcoma. It made it possible to diagnose a benign osteoblastoma, the diagnosis of which was doubtful before the transplant between osteosarcoma and chondroblastoma. It was possible to diagnose the malignancy of a haemangiopericytoma of muscle. Two aggressive tumours--a non-ossifying fibroma and a giant-cell tumour--were rated as benign after transplantation. This technique also allowed a more precise diagnosis of the grade of one chondrosarcoma and one osteosarcoma. Finally, transplantation also made it possible to test the efficacy of chemotherapy. In a patient so treated, the extreme cell proliferation after transplantation to the nude mouse led to a change in the drugs administered.
Rev Chir Orthop Reparatrice Appar Mot 1986
PMID:[Microsurgical transplantation of bone tumors of uncertain prognosis in athymic nude mice]. 346 99

The extent of osteogenic sarcoma has been measured in 30 bones obtained after local resection and compared with pre-operative evaluation. In only one case was the articular cartilage involved and the whole joint was resected. Other cases with a metaphyseal localisation were treated by disarticulation. Articular cartilage appears to provide good protection against local extension. In contrast, the growth cartilage, which was present in 11 cases, was crossed by tumour on three occasions. In only one case of diaphyseal localisation was a resection made across the tumour which had been previously rendered necrotic by chemotherapy. In most of the diaphyseal localisations, the post-operative study revealed that the resection had been over-extensive. Tomodensitometry is not very reliable in the precise evaluation of the extent of diaphyseal involvement.
Rev Chir Orthop Reparatrice Appar Mot 1986
PMID:[Pre- and postoperative anatomo-clinical correlations apropos of 30 conservative resections of osteogenic sarcomas. Surgical inferences]. 346 96

Case report of a central midshaft osteosarcoma of the femur, treated conservatively under Rosen procedure. Bone resection was followed by reconstruction with a deep frozen (-196 degrees) conserved massive homograft, fixed by an interlocked Kuntscher's nail. The purpose of this paper is to expose the advantages of this type of fixation, V.S. conventional nails, or plates. X-Ray showed a bridging bone spindle between host and graft cortical bone, induced by initial stability of the nail, and a rapid fusion after secondary dynamisation of the nail, by removing one screw. We obtained an early functional recovery and a complete and rapid autonomy necessary to allow social and school reinsertion, whatever should the medium or long term presumed survival be.
Rev Chir Orthop Reparatrice Appar Mot 1987
PMID:[Resection-reconstruction of the femur shaft by a massive allograft fixed by an interlocking nail]. 347 Aug 55

The pathologist today has an important role in the treatment of osteosarcoma. He contributes during the operation by advising about the extent of the tumour and after the operation by studying the operative specimen to assess the extent of the tumour, and, when primary chemotherapy has been used, to estimate the effectiveness of the treatment by counting the percentage of viable tumour cells so that the type of chemotherapy used subsequently can be adapted to the situation. Only trained teams can make the best use of these studies.
Rev Chir Orthop Reparatrice Appar Mot 1987
PMID:[The role of the pathologist in the treatment of osteogenic sarcoma]. 347 42

An experimental study has been made to explore the possibility of using plaster or surgical cement as a vehicle for the diffusion of local chemotherapeutic agents in osteosarcoma. In vitro, leeching out of methotrexate from plaster or acrylic cement occurred with a peak during the first few hours followed by a decreasing curve lasting for an average of two weeks. In dogs suffering from a spontaneous osteosarcoma, the loss of substance produced by excision was filled with cement to which methotrexate had been added extemporaneously. This method of administration produced a general diffusion of methotrexate whose blood levels were measured for three to five days. In laboratory rats into which osteosarcomata had been grafted, tablets of plaster containing antimitotic drug were implanted into the tumour, which was left in situ. This made it possible to show that the local chemotherapy was having a true effect, particularly when the antimitotic used was cisplatinum. In patients who had acrylic cement containing methotrexate inserted during operation, local diffusion resulted in very high concentrations, evidenced by the concentration found in fluid obtained from suction drains during the early days after operation.
Rev Chir Orthop Reparatrice Appar Mot 1987
PMID:[Experimental study on osteosarcoma of local chemotherapy diffusing from surgical acrylic cement and plaster]. 348 47

The authors have treated a first series of 46 cases of osteogenic sarcoma of a limb by local resection between 1975 and April 1983. Cases with metastases were excluded. The surgical procedures used for reconstruction are described. The patients were operated on first and then treated by chemotherapy using several schemes of treatment. After an average follow-up of three years, 26 patients appeared to be free of any recurrence or metastasis. The importance of an extensive resection followed by appropriate chemotherapy is stressed. In a second series of 37 cases treated between May 1983 and March 1984, the patients were first treated by chemotherapy (methotrexate in high dosage and CDDP by intra-arterial perfusion) and then operated on. In the second series, the percentage of tumour necrosis seen in resected cases was found to be very high.
Rev Chir Orthop Reparatrice Appar Mot 1985
PMID:[Conservative surgical treatment in osteogenic sarcoma of the limbs]. 386 2

Functional results and survival have been improved in osteosarcoma during the last ten years, thanks to better conservative surgical techniques and more efficient drugs to prevent metastases. Of the several possible programmes of chemotherapy, the authors considered that the T10 programme of Rosen is the most reliable, this author claiming a survival rate of 90 p. 100 with an average follow-up of twenty months. This programme was adopted by the authors in the Paediatric Department of the Gustave Roussy Institute (Villejuif). Thirty one patients were treated and assessed after an average follow-up of 19 months. The results were favourable, only three patients presenting with metastases. One died. Amongst the thirty surviving patients, twenty-three were treated by local resection and eight by amputation.
Rev Chir Orthop Reparatrice Appar Mot 1985
PMID:[Chemotherapy of osteogenic sarcoma]. 391 12


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