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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two patients, aged six and eight years, having metaphyseal osteolytic and osteoblastic multifocal osteosarcoma are described. The condition is named "metaphyseal multifocal osteosarcoma". The metaphyseal areas are the sites of the pathological process. It can be postulated that a certain intensity of growth activity is the predominant factor in this condition and that this accounts for its multicentered presentation.
Br J Radiol 1978 Sep
PMID:Metaphyseal multifocal osteosarcoma. 27 85

The exercretion of urinary total glycosaminoglycans (GAG) in a case of Rothmund Thomson syndrome associated with osteosarcoma was increased about 2--3 times that of normal control. Since the excretion of urinary total GAG in two cases of osteosarcoma was within normal range, the increased excretion of total GAG might be on account of the metabolic disorder of GAG in Rothmund Thomson syndrome. The prominent fractions obtained by Dowex 1 column chromatography from this syndrome were 0.75 M Fr and 1.0 M Fr, in which the major GAG were indicated to be partially degraded forms of heparan sulfate and chondroitin sulfate, respectively.
Tohoku J Exp Med 1978 Sep
PMID:Increased excretion of urinary glycosaminoglycans in a case of Rothmund Thomson syndrome. 28 5

Only 12% of 50 patients lived 5 years or longer. Those who survived the longest were those with the tumor in the distal part of the lower extremity, with a well differentiated or chondroblastic tumor, or those who underwent radical surgery. Patients treated with surgery and chemotherapy lived about 1.5 months longer than those treated with sugery alone and about 1.2 months longer than those who had radiation included in the therapy. For a patient with a diagnosis of osteosarcoma, the prognosis was to be grave, no matter which methods of treatment were used.
Clin Orthop Relat Res 1978 Sep
PMID:Osteosarcoma: a review of 50 patients treated at the University of Alabama in Birmingham Medical Center between 1944 and 1975. 28 Apr 24

A minimum 52 month follow-up is recorded, in a series of 14 patients with classical osteogenic sarcoma treated by limb irradiation followed in the last 2 1/2 weeks of their therapy by prophylactic lung irradiation. Six of these 14 patients survived for more than 52 months.
Clin Radiol 1978 Sep
PMID:Prophylactic lung irradiation in the treatment of osteogenic sarcoma. 28 Apr 28

A brother and sister with osteogenic sarcoma are reported. A review of the literature reveals thirty additional cases of osteogenic sarcoma in familial aggregation, sixteen of sibling relationship. Genetic and environmental etiologic factors of osteogenic sarcoma are discussed.
Johns Hopkins Med J 1979 Sep
PMID:Osteogenic sarcoma in siblings. 28 42

The case of a patient with low back pain and Paget disease of the L5, S1 vertebrae is presented. Electromyography revealed dysfunction in both the paraspinal and gluteal muscles. Postmortem examination showed sarcomatous transformation of the vertebrae with nerve root compression and skeletal muscle infiltration by tumor. The electromyographic abnormalities are correlated with the pathologic findings. The clinical features of neurologic dysfunction in Paget disease of the vertebral column and in osteosarcoma arising in Paget disease of the vertebral column are reviewed. Electromyography can provide valuable information in the evaluation of the patient with Paget disease of the vertebral column who is suspected of having neurologic dysfunction.
Arch Phys Med Rehabil 1979 Sep
PMID:Electromyographic abnormalities in osteosarcoma arising in Paget disease of the vertebral column. 29 86

Parabiosis of rats permits one partner to survive 1000 R X-radiation if the other is shielded. This dose to the previously shielded partner after intervals of 5, 10 or 30 days tests the ability of the first irradiated partner to recover and, in turn, support the second. The effectiveness of this can be measured by the late effects induced in the pair. Lifespan was shortened by 100--150 days following a 5-day interval, by 30 days following a 10-day interval and not shortened following a 30-day interval. The incidence of leukaemia was about 6 per cent in each group, close to that in control pairs. Shortening the interval between the irradiations decreased the average age of death from leukaemia. No solid lymphoid tumours were induced in the doubly irradiated pairs. The incidence of osteogenic sarcoma was 1.6 per cent in controls and 12.9 per cent in the pairs with both partners irradiated.
Int J Radiat Biol Relat Stud Phys Chem Med 1978 Sep
PMID:Late effects of successive massive doses of radiation on parabiont rat pairs. 30 53

The purpose of the present investigation was to study the effect of delay in fixation on the mitotic activity in tumour tissue. A human osteogenic sarcoma, especially suitable for counting of mitoses, grown in athymic nude mice, was fixed with varying delay and the mitotic, prophase, metaphase and ana-telophase indices were determined. An almost exponential decline of the mitotic index was observed with a reduction to 49.4% and 15.0% after respectively 60 and 180 minutes. The proportional incidence of prophases, metaphases and ana-telophases changed so that a relative accummulation of advanced phases occured during the 180 minutes of observation. It is concluded that delay in fixation of a magnitude, which is not uncommon in routine surgical pathology, may allow the majority of mitoses to terminate, resulting in unreliable assessments of mitotic activity.
Acta Pathol Microbiol Scand A 1979 Sep
PMID:Mitotic activity and delay in fixation of tumour tissue. The influence of delay in fixation on mitotic activity of a human osteogenic sarcoma grown in athymic nude mice. 39 73

Diagnosis of primary malignant bone tumors is based on a synopsis of X-ray findings, clinical symptoms, gross pathology and histology. Osteosarcoma, chondrosarcoma, fibrosarcoma and myelogenic sarcomas have a typical symptomatology and can be diagnosed in the radiograph by localisation, mode of extension, alterations of bone and periosteum.
Rontgenblatter 1976 Sep
PMID:[Introduction to x-ray diagnosis of primary malignant bone tumor (author's transl)]. 79 May 26

A case of osteosarcoma of the right mandible is described. The patient had a long-standing fibrous dysplasia (Jaffe & Lichtenstein disease) in that area. The osteosarcoma did not respond to surgical treatment or radiation and continued to grow, causing the death of the patient. This case is of interest because of the correlation between the radiographic image and the 85Sr-uptake on a scintiscan which corresponded exactly to the tumor mass.
Int J Oral Surg 1975 Sep
PMID:Correlation between bone scanning and the radiographic image in the diagnosis of osteosarcoma. 80 78


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