Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Osteosarcoma
is the most frequent primary malignant bone tumor. An increasing body of evidence has suggested that microRNAs (miRNA/miRs) have emerged as critical regulators in the initiation and progression of
osteosarcoma
. The present study explored the biological function of miR-192-5p and
ubiquitin-specific protease 1
(
USP1
), and investigated whether miR-192-5p could directly interact with
USP1
in
osteosarcoma
. The results revealed that miR-192-5p was significantly downregulated in
osteosarcoma
tissues and cell lines, while a reverse expression profile of
USP1
was observed. Ectopic expression of miR-192-5p restrained cell proliferation, apoptosis, migration and invasion. In addition, it increased the sensitivity of
osteosarcoma
cells to cisplatin.
USP1
was also observed to be a direct target gene of miR-192-5p in
osteosarcoma
. Overexpression of
USP1
promoted cell proliferation, apoptosis, migration and invasion, and decreased cell chemo-sensitivity; however, it could be partially reversed via the overexpression of miR-192-5p in
osteosarcoma
cell lines. Taken together, the present study demonstrated that miR-192-5p suppressed the initiation and progression of
osteosarcoma
by targeting
USP1
. Therefore, miR-192-5p may serve as a valuable biomarker and the miR-192-5p/
USP1
axis may function as a novel therapeutic target for
osteosarcoma
.
...
PMID:MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1. 2973 68
