Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aim:
To investigate the effect of
UBE2T
gene on radiotherapy for
osteosarcoma
.
Materials & methods:
Gene Expression Omnibus database, RT-qPCR and immunohistochemical analysis were performed. Cell proliferation and cell cycle experiments were conducted after knockdown of
UBE2T
. Cell scratch, reactive oxygen species production and apoptosis experiments were conducted after the combination of radiotherapy and
UBE2T
silencing. Then the xenograft mode was further conducted.
Results:
UBE2T
was highly expressed in human
osteosarcoma
. Suppression of
UBE2T
inhibited
osteosarcoma
cell proliferation and induced cell cycle arrest at the G2/M phase. Downregulation of
UBE2T
combined with radiation can substantially inhibit clonal formation and migration, and promote apoptosis of
osteosarcoma
cells
in vitro
and
in vivo
.
Conclusion:
UBE2T
downregulation can enhance the radiosensitivity of
osteosarcoma
in vitro
and
in vivo
.
...
PMID:Downregulation of
UBE2T
can enhance the radiosensitivity of osteosarcoma
in vitro
and
in vivo
. 3135 78
