Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Daphnoretin is an active constituent of Wikstroemia indica C.A. Mey., which is widely distributed in the northwest and southwest regions of China. Previous studies have shown that daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells. However, the effect of daphnoretin on human lung cancer cells has yet to be elucidated. In the present study, daphnoretin was observed to inhibit A549 lung cancer cell proliferation in a concentration- and time-dependent manner. Fluorescent microscopy and flow cytometric analysis showed that daphnoretin induced A549 cell apoptosis in a concentration-dependent manner. Western blot analysis also revealed that daphnoretin induced apoptosis through the regulation of the B-cell lymphoma-2 gene family in A549 cells. These findings indicate that daphnoretin may have potential as a therapeutic agent for the management of lung cancer.
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PMID:Effect of daphnoretin on the proliferation and apoptosis of A549 lung cancer cells in vitro. 2512 Jun 73

The regulation of Daphnoretin on specific tumours (e.g. cervical cancer, lung cancer, osteosarcoma) has been documented, which still remains unclear for colon cancer cells. Our study explored the suppression of Daphnoretin and its molecular mechanism on the proliferation, apoptosis, invasion and migration of human colon cancer cell line HCT116. Our report showed the activity of HCT116 declined with time- and dose- dependence after Daphnoretin intervention, and a rise in G0/G1 ratio and decrease in G2/M ratio was observed. Daphnoretin-treated HCT116 had declined invasion and migration, increased apoptosis rate, and variations in gene expressions related to the Akt signal pathway. Those results indicated that Daphnoretin can inhibit the proliferation, invasion, and migration of HCT116 and promote its apoptosis by regulating the activity of Akt signal pathway.
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PMID:Daphnoretin: An invasion inhibitor and apoptosis accelerator for colon cancer cells by regulating the Akt signal pathway. 3084 14