Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Osteosarcoma
is a mesenchymally derived, high-grade bone sarcoma that is the most frequently diagnosed primary malignant bone tumor. Today, chemoprevention is regarded as a promising and realistic approach in the prevention of human cancer. Previous studies have suggested ellagic acid (EA) and
Sennoside B
have potential in this regard. The aim of the present study was to elucidate the anti-
osteosarcoma
effects of EA and
Sennoside B
by using Saos-2 and MG63
osteosarcoma
cells. It was identified that EA or
Sennoside B
treatment could inhibit the growth, migration and invasion of the cells, and induce G
1
cell cycle arrest by repressing the transcription of c-Jun. These results may provide a cellular basis for the application of EA or
Sennoside B
in the treatment of patients with
osteosarcoma
.
...
PMID:Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c-Jun. 2996 61
