Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Biological characterization of a transplantable hamster osteosarcoma Os515 which had been induced by BK virus was attempted, and usefullness of this tumor was confirmed as an experimental model of treatment of osteosarcoma. All the hamsters with this tumor died of spontaneous lung metastasis. The chest X-ray picture of a tumor-bearing hamster visualized diffuse metastasis in the whole lungs 30 days after transplantation. The development of lung metastases was monitored by chest X-ray after marginal excision of subcutaneously transplanted tumors or after radical disarticulation of a tumor-bearing hind limb. Slow-growing nodular lung metastases were seen on X-ray pictures when the subcutaneous tumors were resected 1 or 2 weeks after transplantation, whereas fast-growing diffuse metastases were seen when the tumors were not resected at all or resected 3 weeks after transplantation. Nodular lung metastases occurred in a small number of animals long after the early radical disarticulation of a tumor-bearing leg.
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PMID:[Biological characterization of a hamster osteosarcoma Os 515--development of lung metastasis]. 386 15

Nodular masses and granulomas of the esophagus are among the most frequent lesions caused by Spirocerca lupi, a nematode parasite of dogs, and neoplastic transformation of these granulomas to osteosarcoma or fibrosarcoma has been described. In this study, we developed a xenograft murine model of S. lupi-associated sarcoma. Samples of esophageal fibrosarcoma and osteosarcomas were excised from three dogs diagnosed with spirocercosis. These sarcomas were inoculated into three groups of 6-week-old NOD/SCID mice to create three tumor lines of S. lupi-associated sarcomas. Mice in all groups developed tumors after inoculation, and the cell lines could be further propagated as second-generation xenografts. We successfully established xenograft murine models of three different lines of S. lupi-associated sarcoma that offer readily available sources of these tumors for further experiments. This resource will facilitate studies on the malignant transformation of the granulomas, establishment of efficient chemotherapy and radiotherapy regimens, and identification of diagnostic molecular markers.
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PMID:Murine xenograft model of Spirocerca lupi-associated sarcoma. 1642 46