Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
DDX46
, a member of the DEAD-box (DDX) helicase family, is involved in the development of several tumors. However, the exact role of
DDX46
in
osteosarcoma
and the underlying mechanisms in tumorigenesis remain poorly understood. Thus, in the present study, we explored the role of
DDX46
in
osteosarcoma
and the underlying mechanisms. Our results demonstrated that the expression levels of
DDX46
in both mRNA and protein were greatly elevated in human
osteosarcoma
tissues and cell lines. Knockdown of
DDX46
obviously inhibited
osteosarcoma
cell proliferation and tumor growth in vivo. In addition, knockdown of
DDX46
also significantly suppressed migration and invasion in
osteosarcoma
cells. Furthermore, knockdown of
DDX46
substantially downregulated the phosphorylation levels of PI3K and Akt in SaOS2 cells. In summary, the present results have revealed that
DDX46
plays an important role in
osteosarcoma
growth and metastasis. Knockdown of
DDX46
inhibited
osteosarcoma
cell proliferation, migration, and invasion in vitro and tumor growth in vivo. Therefore,
DDX46
may be a potential therapeutic target for the treatment of
osteosarcoma
.
...
PMID:Knockdown of DDX46 Inhibits the Invasion and Tumorigenesis in Osteosarcoma Cells. 2769 93
