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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Patellar tumors represent an uncommon etiology of anterior knee pain and their diagnosis is often delayed. We present an unusual case of conventional osteosarcoma arising in the patella of a 47-year-old man. The patient presented with a 1-year history of increasing anterior knee pain and swelling. Plain radiographs revealed a multi-locular lytic lesion in the inferolateral side of the patella. Computed tomography scans demonstrated an intraosseous lytic lesion with cortical thinning/breakthrough anteriorly. On magnetic resonance imaging, the lesion exhibited low signal intensity on T1-weighted images and heterogeneous high signal intensity on T2-weighted images. Fluid-fluid levels were also observed on T2-weighted images. Contrast-enhanced fat-suppressed T1-weighted images demonstrated strong enhancement of the lesion. These imaging features were suggestive of a benign condition; however, the diagnosis of osteosarcoma was confirmed by histopathology. After neoadjuvant chemotherapy, a wide resection with a free anterolateral thigh flap was performed. The patient subsequently underwent adjuvant chemotherapy and had no evidence of local recurrence or distant metastasis six months after surgery. Our case highlights the difficulty in the diagnosis of patellar osteosarcoma and the importance of performing a biopsy before definitive treatment.
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PMID:Osteosarcoma of the patella mimicking giant cell tumor: imaging features with histopathological correlation. 2477 73

Parosteal osteosarcoma originates on the surface of long bones and spares the medullary canal. Its peak incidence occurs in the third decade of life and it is more frequent in females than males. The juxtacortical variety of parosteal osteosarcoma is one of the most common ones, accounting for 1-6% of all osteosarcomas. The classical radiographic appearance of osteosarcoma includes high ossification density and a lobed mass, usually in the posterior aspect of the distal femur, sparing the medullary canal. We report herein the case of a 31 year-old male patient with a clinical picture that included left knee pain and who was seen as outpatient. He was started on treatment for enbloc resection of the tumor and implantation of the OSS (Orthopedic Salvage System) prosthesis. Treatment consisted of broad resection of the proximal tibia, of approximately 14 cm, as well as the implantation of a nonconventional modular tibial prosthesis. Both the radiographic and the clinical results were good and appropriate at the three week follow up.
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PMID:[Paraosteal osteosarcoma of the tibia treated with the OSS prosthesis. Case report]. 2602 Oct 95

Osteoblastoma is a rare neoplasm, accounting for only 1% of the primary bone neoplasms. We report a case of periosteal osteoblastoma, a rare subtype of osteoblastoma. To the best of our knowledge, only 30 cases of periosteal osteoblastoma appear in the English literature. Our case is that of a 41-year-old male with vague intermittent knee pain over a two-year period. Diagnostic imaging revealed an aggressive-appearing lesion in the posterior distal femur, which was initially considered to be a surface osteosarcoma. Roentgenographic, CT, MRI, and bone scan features are presented.
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PMID:Periosteal osteoblastoma: Multimodal imaging of a rare neoplasm. 2730 37

In brief Chronic knee pain among active brief adolescents may be caused by a wide spectrum of conditions that range from generally benign, self-limited disorders, such as Osgood-Schlatter disease, to malignant osteosarcoma. Benign disorders account for the majority of knee pain in the adolescent athlete, and most causes are readily diagnosed. However, recognizing and treating the less common-often more serious-causes of chronic knee pain may be a greater challenge.
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PMID:Chronic Knee Pain in Active Adolescents Don't Forget the Uncommon Causes. 2743 43

A 20 year old man suffered severe right knee pain, especially when his right foot touched ground. The MRI findings suggested periosteal osteosarcoma, which led to a staging FDG PET/CT. The images showed not only a hypermetabolic right knee lesion but also focally elevated activity in select muscles, which was attributed to altered biomechanics. The resected lesion was pathologically proven as periosteal chondrosarcoma instead of periosteal osteosarcoma. In a follow-up period of 4 years after the surgery, there was no recurrent disease, nor any abnormality in the muscles which showed focal FDG activity on the initial FDG PET/CT.
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PMID:Unusual Focal Muscle FDG Activity Related to Altered Biomechanics. 3051 74


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