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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Following amputation of a lower extremity for osteogenic sarcoma, the lumbar muscles receive an asymmetric strain. This predisposes to low-back-pain. When this occurs, tumour-recurrence must be excluded. This report demonstrates the usefulness of high-resolution computed tomography (CT) in this clinical situation.
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PMID:Computed tomography in low-back-pain after femur-amputation for osteogenic sarcoma. 295 48

Analysis was made of 37 cases of chondrosarcoma of the maxilla or the mandible. The most common complaint at initial presentation was the presence of a mass. Pain was a presenting symptom in less than half of the patients. The usual roentgenographic appearance was an ill-defined radiolucency with mottled areas of calcification. When teeth were involved, some cases showed a widened periodontal membrane space on periapical dental radiographs. Histologically, the tumors usually showed recognizable cartilage and a lobular growth pattern, but cellular evidence of malignancy was often subtle. Radical surgery was the treatment of choice. Prognosis appears best when such surgery is performed soon after the onset of symptoms. Also, patients presenting with mandibular tumors and with tumors of the better differentiated histologic grades enjoy a better survival time. Neck dissection is probably not warranted for chondrosarcoma of the jaws. Contrary to the relationship between these two tumors in other skeletal sites, the overall prognosis for chondrosarcoma of the jaws does not appear to be as good as that for osteosarcoma of the jaws.
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PMID:Chondrosarcoma. II. Chondrosarcoma of the jaws: analysis of 37 cases. 313 5

We reviewed the clinical features and results of treatment in 24 patients with osteogenic sarcoma of the spine treated over a 35-year period. There were 14 male and 10 female patients 13 to 71 years old. The tumor arose de novo in 13 patients and was secondary to other conditions in 11. All patients presented with pain, and 16 (67%) had neurological deficits. Patients were divided into two treatment groups. Thirteen patients treated from 1949 to 1977 usually underwent limited tumor resection and external radiation therapy. The second group, 11 patients treated from 1978 to 1984, underwent more aggressive surgical resection and received combination chemotherapy as well as local radiation to the tumor bed. In the second group, there were 5 long term survivors, and only 1 patient developed metastatic disease while on therapy. Failure to obtain local control was the major cause of treatment failure. Complete surgical resection of the tumor by spondylectomy and combination chemotherapy offer the best prospect for cure of osteogenic sarcoma of the spine.
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PMID:Combined treatment of osteosarcoma of the spine. 321 69

A 34-year-old man developed a spindle-cell sarcoma originating in a preexisting lesion of monostotic fibrous dysplasia. A review of the literature reveals 83 cases of a malignant degeneration in fibrous dysplasia; osteosarcoma was the most common type of tumor. The next most common were fibrosarcoma and chondrosarcoma. The malignant tumor usually developed in the third or fourth decade of life. The most frequent anatomic sites were the craniofacial bones, the femur, and the tibia. Twenty-three of the 83 cases were treated with local radiation. In fibrous dysplasia, any abrupt alteration in the clinical course, manifested by pain and swelling, raises the possibility of malignant degeneration.
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PMID:Malignant transformation of fibrous dysplasia. A case report and review of the literature. 327 58

Primary osteosarcoma of bone has originated in the spine in only a few patients. This report concerns twenty-seven of thirty patients who had the original diagnosis made and surgical treatment, if any, performed at the Mayo Clinic. The patients' ages ranged from eleven to eighty years. Pain in the area of involvement was the first symptom in all patients. In addition, nineteen patients (70 per cent) had neurological symptoms and signs when they were first seen. All patients had a surgical biopsy of the lesion, often combined with decompressive laminectomy. Twenty-one of the twenty-seven patients received postoperative radiation therapy in various dosages. Only five patients received adjunctive chemotherapy. All but one patient died of the disease, with a median length of survival of ten months (range, one to thirty-eight months). Although rare, osteosarcoma of the spine can usually be suspected on roentgenograms, and then the most aggressive therapy is justified.
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PMID:Osteosarcoma of the spine. 345 29

The first case of bilateral metachronous periosteal osteosarcoma (OS) is reported. A 14-year-old white boy presented with a 1-month history of pain and swelling in his right thigh. Periosteal OS was diagnosed on a basis of the radiologic and pathologic findings. Treatment was with local resection and total hip replacement after a short course of high-dose methotrexate; multi-agent chemotherapy was continued postoperatively for 3 months. He remained well for 3 years. He then represented with a mass in the left femur that had been slowly growing for about 1 year. Radiologic and biopsy studies showed periosteal OS. Full investigations showed no evidence of metastatic disease. Treatment consisted of local resection without chemotherapy. He remained well for 6 months after the second excision until developing multiple pulmonary metastases. All further therapy was refused. The question as to whether the second tumor was a new primary lesion or a metastasis is discussed, together with possible differential diagnoses.
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PMID:Bilateral metachronous periosteal osteosarcoma. 346 Jun 85

The authors evaluated a new protocol of neoadjuvant chemotherapy for osteosarcoma, easier to manage and different from T10. The good results obtained with the postoperative ADR-CDDP association led us to undertake a pilot study between 1982 and 1984, using ADR-CDDP as preoperative chemotherapy. The records of sixteen patients were available for follow-up. The average age of the patients was 19.9 years. Patients received two or three preoperative courses, and a total of six identical courses. Tolerance was good. Pain usually disappeared but this was often misleading because associated with radiological and/or clinical tumor progression, low histological necrosis or poor outcome. The continuous disease-free survival actuarial rate was less than 57 and 40% at 18 months and two years respectively. The actuarial survival rate was 87% at one year and 65% at two years respectively. Disappointing results of this preoperative protocol, compared to results with the SO4 78 or T10 protocols for example, led to publish these data early in order to underline their potential dangers. As a result, we stopped our study. The charter of pilot studies justifies this publication. As well, these data point out the necessity of very close follow-up of neoadjuvant chemotherapy by sophisticated medical imaging. Neoadjuvant chemotherapy, if ineffective, must be stopped early, and should lead to surgery, followed by adequate postoperative chemotherapy.
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PMID:[Pre and postoperative chemotherapy of osteosarcoma with an adriamycin-cisplatin combination. Risks of a neoadjuvant chemotherapy which is not sufficiently effective]. 346 71

The authors report 12 cases (8 men and 4 women) of sarcomatous degeneration in Paget's bone disease, with an average age of 72.3 years. Sarcomatous degeneration occurred often in polyostotic Paget's disease, and osteitis deformans was seen in 4 cases. Femur and pelvis were the most affected bones. Pain was a constant feature, whereas tumefaction and fracture were less common. Osteolytic lesions were more frequent than condensed or mixed lesions and radiological signs of malignancy were usually found. Seven cases were histologically classified as osteogenic sarcoma and 3 cases as fibrosarcoma. Electron microscopy was performed on 2 osteogenic sarcomas and in 1 case revealed microcylindrical inclusions in Pagetic osteoclasts and in multinucleated giant tumor cells, but none in mononucleated tumor cells. The average survival time for the patients in this study was only 4.5 months.
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PMID:Sarcomatous degeneration in Paget's bone disease. 347 35

A retrospective study of 88 cases of extraskeletal osteosarcoma revealed that this tumor affects adults almost exclusively, with a high incidence in patients older than 50 years, and is slightly more common in males (58%) than in female patients. The tumor occurred principally as a soft tissue mass in an extremity, with a predilection for the thighs (lower extremity, 46.6%; upper extremity, 20.5%) and the retroperitoneum (17%). Most were deep-seated and were firmly attached to the fascia, but occasionally they were freely movable and confined to the subcutis or dermis. Nearly all presented as an insidiously growing mass rarely causing pain or tenderness. The preoperative duration of symptoms ranged from 2 weeks to 25 years (median, 6 months). In 17 cases, it exceeded 2 years. A history of prior trauma to the site of the tumor was stated in 11 of the 88 cases (12.5%) and of radiation in five cases (5.7%). Microscopically, the tumors contained varying amounts of neoplastic osteoid and bone, sometimes together with islands of malignant-appearing cartilage. Like osteosarcoma of bone, extraskeletal osteosarcoma showed a striking variation in histologic appearance and focally resembled malignant fibrous histiocytoma, fibrosarcoma, and malignant schwannoma. Follow-up information was available for 65 patients. Eight (12.3%) patients were alive with no evidence of recurrence; 12 (18.5%) patients were alive with one or more recurrences; and five (7.6%) were alive with metastases. Twenty-eight of the tumors (43%) recurred and 39 (63%) metastasized. Forty (61.5%) of the patients with follow-up information had died, 36 from the tumor and four from miscellaneous causes. The prevailing sites of metastases were the lung, the regional lymph nodes, and bone.
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PMID:Extraskeletal osteosarcoma. 347 57

Telangiectatic osteosarcoma, being a subtype of osteosarcoma, is rare. In this paper, one case is reported. The patient, a sixteen year old man, was admitted into our hospital in 1983 because of swelling and pain in the left knee for 3 months. On physical examination, a mass, 7 x 5 x 5 cm in size, was found in the distal end of the left thigh. A misdiagnosis of hemangioma of the bone was made by puncture biopsy before operation. After three months, the disease progressed and amputation had to be performed. The pathological diagnosis of telangiectatic osteosarcoma was established after operation. Finally, clinical and roentgenographic manifestations, histological and ultrastructural findings, biologic behavior, diagnosis and differential diagnosis are discussed. In particular, the differentiation from aneurysmal bony cyst and hemangioma of the bone is emphasized.
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PMID:[Telangiectatic osteosarcoma--a case report]. 348 2


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