Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Epulides were diagnosed and surgically removed in 25 dogs. Histologic examination of the epulides indicated that 40% (10/25) were acanthomatous, 32% (8/25) were ossifying, and 28% (7/25) were fibromatous. Recurrence of the tumor directly resulted in the death of 2 dogs. One of these dogs died of malnutrition 13 months after removal of an ossifying epulis, and regrowth of an acanthomatous epulis that was not resected completely resulted in malnutrition and death in another dog 6 months after surgery. Malignant transformation was observed in a third dog 6 months after removal of an ossifying epulis when an osteosarcoma developed where the epulis had been removed. The range of survival was 6 to 134 months, mean survival time was 43.1 months, median survival time was 49 months, and 1-year survival rate was 92%. Satisfactory long-term tumor control was achieved by aggressive surgical treatment of epulides.
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PMID:Surgical treatment of epulides in dogs: 25 cases (1974-1984). 358 89

Acanthomatous epulides in 39 dogs were treated with orthovoltage x-rays. The acanthomatous epulis recurred in only 3 dogs, 2 of which were successfully retreated with x-rays. Malignant tumors other than acanthomatous epulis developed at the site of the irradiated acanthomatous epulis in 7 of the dogs. Five of the tumors were squamous cell carcinoma, one was a fibrosarcoma, and one was an osteosarcoma. The range of survival times (1 to 102 months), mean survival time (38 months), median survival time (37 months), 1-year survival rate (85%), and 2-year survival rate (67%) were encouraging and suggested that the described treatment was satisfactory for acanthomatous epulides. Cause of death in most dogs was not related to the acanthomatous epulis.
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PMID:Orthovoltage radiotherapy of acanthomatous epulides in 39 dogs. 642 60

The most common orofacial tumors of dogs are malignant melanoma, squamous cell carcinoma, fibrosarcoma, osteosarcoma, and acanthomatous epulis. These tumors vary significantly in their metastatic potential, but are consistently locally invasive. Bone involvement is common, and complete excision often requires partial mandibulectomy or partial maxillectomy. Survival times after surgery are most strongly influenced by tumor type (or metastatic rate) and tumor location. Recent large retrospective studies have reported median survival times ranging from 4.6 to 26 months. The most common oral tumor of cats is squamous cell carcinoma. This is a highly invasive tumor that occasionally can be effectively treated with surgery alone, but that often requires a combination of surgery and radiation therapy.
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PMID:Principles of oncologic orofacial surgery. 963 45

Osteosarcoma (OS) occurs most often in the long bones. OS of the jaws has clinical and biologic aspects different from those of the long bones. They tend to occur at an older mean age, pain and swelling are more typical, and prognosis is more favorable. Nearly all OS shows a very prominent central intramedullary bone component. Only rarely are juxtacortical (peripheral) OS located in the jaws. There are 2 main types of juxtacortical OS, periosteal and parosteal. We present 2 cases of OS of the jaws where the clinical, radiologic, and histologic findings pointed to a diagnosis of periosteal OS. Both patients presented, in fact, with lesions located superficially on the bone surface with no marrow involvement. Both tumors were characterized by the presence of a moderately differentiated chondroblastic tumor with foci of osteoid and bone formation. Periosteal OS should be differentiated microscopically from periosteal chondrosarcoma, intramedullary OS with periosteal extension, high-grade surface OS, and parosteal OS. The clinical differential diagnosis was done, in these cases, for epulis, gingival tumors, peripheral odontogenic fibroma, peripheral ossifying fibroma, pyogenic granuloma, peripheral giant cell granuloma, and mesenchymal malignant tumors.
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PMID:Periosteal osteosarcoma of the jaws: report of 2 cases. 1071 25

Juxtacortical osteogenic sarcoma of bone is a relatively uncommon form of osteogenic sarcoma. In the jaw bones, it is extremely rare. Here, we present a case of Juxtacortical Osteogenic Sarcoma of mandible in a 45 year old man which presented as an epulis in the mandibular incisor region.
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PMID:Juxtacortical osteogenic sarcoma of mandible. A case report. 1130 30

In this retrospective study of 57 dogs irradiated for oral acanthomatous epulis, 2 (3.5%) dogs developed a second tumor (sarcoma, osteosarcoma) in the radiation treatment field at 5.2 and 8.7 years after the end of radiation therapy. As opposed to previous reports, no second epithelial tumors developed in the radiation treatment field. There is a risk of radiation-induced carcinogenesis, but it appears that it is a relatively low risk and an event that occurs years after radiation therapy. Radiation-induced tumors are of more concern in younger dogs that undergo radiation therapy for tumors that are radioresponsive, such as acanthomatous epulis, where long-term survival is expected. The only statistically significant variable in the survival analysis was age, with dogs less than 8.3 years old having a significantly longer median overall survival (2322 days) than dogs older than 8.3 years (1106 days; P<0.0001).
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PMID:Malignant tumor formation in dogs previously irradiated for acanthomatous epulis. 1537 65

This retrospective study of a series of 18 cases aimed to describe the clinical and pathological findings of oral tumours in rabbits, as there have been few reports detailing spontaneous oral tumours in this species. A total of 13 different tumour types were diagnosed: squamous cell carcinoma (three), ameloblastoma (two), fibrosarcoma (two), osteosarcoma (two), cementoma (one), complex odontoma (one), giant cell epulis (one), sarcoma (one), chondrosarcoma (one), trichoepithelioma (one), papilloma (one), malignant melanoma (one) and basal cell carcinoma (one). Odontogenic tumours were relatively common in this study as compared to the oral tumours typically identified in dogs and cats. The most common clinical sign in this study was feeding abnormalities. Surgical excision and radiation therapy were found to be effective in rabbits.
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PMID:Spontaneous oral tumours in 18 rabbits (2005-2015). 3173 10