Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 66-year-old woman with a history of mitral valve replacement with a Starr-Edwards ball valve 25 years ago was treated for refractory heart failure but died of right heart failure. At autopsy, primary pulmonary artery sarcoma was found in the right ventricular outflow tract, main pulmonary trunk, and bilateral pulmonary artery, and had invaded the aortic arch. The pathohistologic diagnosis was osteosarcoma. Echocardiography, chest computed tomography and right ventriculography performed 1 year before death did not reveal the presence of a tumor in the pulmonary artery. The history of this patient shows that primary pulmonary artery sarcoma grows rapidly, with, in this case, the patient dying within 1 year of its appearance.
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PMID:Primary pulmonary artery sarcoma. 962 7

A 68-year-old woman with symptoms of dyspnea and peripheral edema was referred to our hospital. Chest computed tomography (CT) scans revealed a huge mass occupying the pulmonary trunk and invading the right main pulmonary artery, with metastatic nodules in the left main and left lower pulmonary artery. She was given a diagnosis of pulmonary thromboembolism and was anticoagulated to no effect, which suggested a neoplasm. Palliative resection of the tumor was carried out even though she was in serious condition with right ventricular failure, liver congestion, renal dysfunction, and coagulopathy disorder. The histopathology, postoperative systemic CT scan, and bone scintigram provided a definitive diagnosis of a primary right ventricle osteosarcoma. Primary cardiac osteosarcoma has a poor prognosis, and this patient was at an advanced stage with pulmonary metastases. Surgical intervention should offer these patients significant palliation to relieve the clinical symptoms due to obstruction.
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PMID:Right ventricular failure due to primary right ventricle osteosarcoma. 1744 67

Right atrial cardiac osteosarcoma is a rare intracardiac tumor that can be difficult to diagnose. This report describes a 20-year-old man who was referred to our hospital with symptoms of heart failure. Echocardiography revealed a mass adhering to the right arterial septum that extended into the right ventricle and inferior vena cava. Right ventricular failure and worsening symptoms indicated the need for emergency life-saving surgery. Thereafter, the associated symptoms dramatically and rapidly diminished, and two days later the patient had recovered sufficiently to walk unaided. The short-term results of surgical tumor excision were excellent.
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PMID:Primary right atrial cardiac osteosarcoma with congestive heart failure. 1916 34