Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The GMR editorial staff was alerted about some manuscripts that were found to be substantially equal. The Publisher and Editor decided to retract these articles in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation, we have strong reason to believe that the peer review process was failure and, after review and contacting the authors, the editors of Genetics and Molecular Research decided to retract these articles. The authors and their institutions were advised of this serious breach of ethics. The articles containing plagiarism in common with other publications are: Peng ZA, Lu RB, Xiao DM and Xiao ZM (2016). Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma. Genet. Mol. Res. 15 (1): gmr15017480 - DOI: 10.4238/gmr.15017480. Man HB, Bi WP and Man HH (2016). Decreased microRNA-198 expression and its prognostic significance in human glioma. Genet. Mol. Res. 15 (2): gmr.15027656 - DOI: 10.4238/gmr.15027656. Tang T, Zhang GC, Li CF, Liu YF, et al. (2016). Decreased miR-452 expression in human colorectal cancer and its tumor suppressive function. Genet. Mol. Res. 15 (2): gmr.15027730 - DOI: 10.4238/gmr.15027730. Ma YB, Song DW, Nie RH and Mu GY (2016). MicroRNA-32 functions as a tumor suppressor and directly targets EZH2 in uveal melanoma. Genet. Mol. Res. 15 (2): gmr.15027935 - DOI: 10.4238/gmr.15027935. Wang XJ, Xia M and Bi WP (2016). Decreased expression of miR-874 and its tumor suppressive function in human colorectal cancer. Genet. Mol. Res. 15 (2): gmr.15028077 - DOI: 10.4238/gmr.15028077. Zhuo HC, Song YF, Ye J, Lai GX, et al. (2016). MicroRNA-154 functions as a tumor suppressor and directly targets HMGA2 in human non-small cell lung cancer. Genet. Mol. Res. 15 (2): gmr.15028173 - DOI: 10.4238/gmr.15028173.
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PMID:RETRACTION of articles with plagiarism in common with other publications. 2732 92

The cancers are the leading cause of disease-related deaths worldwide with a high risk of morbidity and mortality. Long noncoding RNAs (lncRNAs) play a critical role in a wide range of biological processes, including tumorigenesis. HOXA11-AS (NCRNA00076), the antisense strands of HOXA11 gene, was initially revealed in a mouse embryonic cDNA library in 2009 and it was a fairly novel lncRNA. This review summarized the advanced research progression concerning the expression and role of HOXA11-AS in different human malignancies. The expression of HOXA11-AS is aberrantly altered in many cancers, either as a tumor suppressor or as a tumor accelerator. The different underlying mechanism of HOXA11-AS in different cancers (including, nonsmall cell lung cancers, osteosarcoma, uveal melanoma, glioma, hepatocellular carcinoma, gastric cancer, breast cancer, cervical cancer, ovarian cancer, colorectal cancer, ovarian cancer, and glioblastoma) was also detailed. These findings lead us to conclude that HOXA11-AS participate in the complex network of cancers and plays an important role in the tumorigenesis and progression. Functional HOXA11-AS could be a promising biomarker for early detection as well as prognosis evaluation in cancer patients. Future HOXA11-AS-targeted intervention may become a valuable novel therapeutic tool, improving the clinical management of cancers.
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PMID:HOXA11 antisense long noncoding RNA (HOXA11-AS): A promising lncRNA in human cancers. 2999 90