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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Metastasis of osteogenic sarcoma to the mandible is extremely rare. A case of mandibular metastasis of an osteogenic sarcoma of the left fibula is presented. The patient, a 17-year-old Japanese girl, was suffering from a metastatic gingival tumor, 3 by 5 cm. in size, with ulceration. Eventually, there were multiple metastases not only to the mandible but also to the thoracic vertebrae, lumbar vertebrae, sacrum, zygomatic bone, clavicle, sternum, humerus, rib, femur, tibia, lung, and meninges.
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PMID:Mandibular metastasis of osteogenic sarcoma. Report of a case. 80 65

A primary osteosarcoma of the meninges based on clinical, light, and ultrastructural findings is reported. The neoplasm appears to complete Cushing and Eisenhardt's postulate and expectation of a malignant counterpart of osteoblastic meningioma. The neoplasm lends support to the concept of a primitive multipotential mesenchymal cell in the meninges capable of giving rise to every variety of neoplasms within that potential.
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PMID:Osteosarcoma of meninges: clinical, light, and ultrastructural observations of a case. 693 39

A search of the rat tumor literature revealed no papers on naturally occurring primary osteosarcoma of meninges. In humans, this tumor, arising primarily from the meninges, is unusual; only two cases have been reported. We report on a spontaneously occurring osteosarcoma arising from meninges in a 2-year-old female albino rat. The diagnosis was made on the basis of gross, microscopic, and ultrastructural findings. The diagnosis of this neoplasm is supported by the fact that a primitive mesenchymal cell in the meninges is capable of giving rise to a wide variety of neoplasms.
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PMID:Spontaneous osteosarcoma of the meninges in an albino rat. 777 Oct 66

Primary intracranial osteosarcoma not originating in the skull is a distinctly rare tumour, as is post-irradiation sarcoma of short latency. The authors report the case of a 56 year old caucasian male who underwent resection of a glioblastoma of the left temporal region and was subsequently administered partial field external beam radiation therapy (XRT) to a total dose of 5940 cGy. Seven months following the completion of XRT, an enhancing region adjacent to the surgical site was noted on followup magnetic resonance images (MRI), one which increased in size on serial studies. Initial biopsy of the dural lesion adjacent to the temporal resection site revealed a sarcoma with a suggestion of osseous differentiation. Subsequent reoperation with resection of the lesion showed it to be a primary meningeal tumour, and histological evaluation of the lesion demonstrated an osteosarcoma. Immunohistochemical staining for p53 protein performed on both the original glioblastoma and the subsequently resected osteosarcoma showed widespread nuclear positivity. The clinical, radiographic and pathologic features of this unusual case are discussed. Meningeal osteosarcoma should be included among the rare secondary sarcomas of the meninges which may be associated with malignant glioma.
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PMID:Osteosarcoma of the meninges in association with glioblastoma. 926 63

To our knowledge, this is the third reported case of spinal intradural osteogenic sarcoma. The two prior reported cases had a history of iophendylate injection whereas this patient did not. Other cases involved the cranial meninges, not the spine. This is the first reported case of intradural osteosarcoma in the absence of iophendylate injection. We report our workup, diagnosis, and treatment. We also include a video demonstrating the intraoperative invasion of tumor and dural erosion.
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PMID:Intradural osteogenic sarcoma in the lumbar spine. 3092 31

Although rare in everyday practice, malignancies that classically arise from bone or cartilage have been reported to arise de novo in various soft tissues in the body, resulting in a diagnostic challenge for the clinician, radiologist, and pathologist. Differential diagnoses of bone tumors often depend on anatomic location of the lesion. For example, the classic location of osteosarcoma is in the metaphysis of long bones about the knee. Histologically osteosarcoma is characterized by tumor cells that directly produce osteoid, bone, or cartilaginous matrix. In extraskeletal osteosarcoma, the clinical and radiologic picture is very different from a conventional osteosarcoma. They occur in older patients, present as a soft tissue mass often coincidentally following trauma and have a worse prognosis. The imaging characteristics are often nonspecific with mineralized elements in a well-defined soft tissue mass. The mineralized elements may or may not be visible. Magnetic Resonance sequences demonstrate a well circumscribed soft tissue mass with hemorrhagic and enhancing solid components. The pathologic features of extraskeletal osteosarcoma on a microscopic scale are identical to that of skeletal lesions. Likewise, conventional chondrosarcomas present in older patients with a growing, painful soft tissue prominence most commonly involving the long tubular bones. In extraskeletal chondrosarcoma however, the presentation is in somewhat younger patients with a painful soft tissue prominence typically in the head (meninges), neck, or upper leg. The pathologic features are most often that of a myxoid chondrosarcoma which is characterized by strands of small cells over a myxoid matrix. Imaging features include chondroid matrix, heterogenous contrast enhancement, and amorphous internal calcification on Computed Tomography. On Magnetic Resonance sequences the matrix has a low signal on all sequences, and variable inhomogeneity depending on grade of the lesion. Other extraskeletal bone tumors include Ewing's sarcoma and osteoid osteoma amongst other lesions. Although these malignancies may be rare clinical entities, they often exhibit characteristic clinical, imaging, and histopathological findings although differing in treatment and prognosis. Knowledge of these and other common mimicking lesions will help guide the clinician and radiologist to make an accurate diagnosis.
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PMID:Bone Tumors Occurring in the Soft Tissues: A Review of the Clinical, Imaging, and Histopathologic Findings. 3266 61