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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study was to evaluate the CT characteristics of metastatic pulmonary tumor. The study included 163 cases. Analysis of the distribution of 1265 metastatic nodules observed the conventional and helical CT with 10 mm slice thickness showed that they were distributed mainly below the carina and external peripheral lung field. The relationship between the characteristics of the margins of the metastatic nodules and primary tumors was evaluated in 280 nodules with high-resolution CT(HRCT). The margins were smooth in 88% of thyroid cancers, 85% of hepatocellular carcinomas and 75% of renal cell carcinomas, and irregular in 75% of pharyngolaryngeal cancers, 62% of colon cancers and 58% of breast cancers. HRCT findings were correlated with histology in 23 surgically resected metastatic nodules. The well-defined smooth margin on HRCT histologically corresponded to the expanding type, while the irregular margin corresponded predominantly to the alveolar space-filling type. Among other CT findings calcification was seen in colon cancer and osteosarcoma, and cavitation in pharyngolaryngeal cancer, colon cancer angiosarcoma, pancreatic cancer and endometrial uterine cancer. The author concludes that CT is useful for observing the morphologic features of metastatic pulmonary nodules which seem to reflect the underlying pathologic characteristics and thus contributes to the diagnosis.
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PMID:[CT of metastatic pulmonary tumor: morphology, HRCT and histological correlation]. 901 64

Radiation therapy (RT) is commonly used to treat malignant tumors, but it leads to side effects and complications. Postradiation sarcomas developing from a previously irradiated area are especially vicious to deal with, though their occurrence is rare. This article focuses on the clinical manifestations, pathological characteristics, and therapeutic effects concerning postradiation soft tissue sarcomas (PRSTSs). A series of 14 PRSTSs treated between 1979 and 2000 in five hospitals in Japan were analyzed. Their histological types were malignant fibrous histiocytoma (eight cases), extraskeletal osteosarcoma (four cases), fibrosarcoma (one case), and leiomyosarcoma (one case). The primary diagnoses, RT history, latent period, and outcome of treatment were studied retrospectively. The original tumors included uterine cancer (seven cases), breast cancer (four cases), synovial sarcoma (one case), squamous cell carcinoma (one case), and Hodgkin's disease (one case). There were 13 women and 1 man, with ages ranging from 23 to 77 years (mean 58 years) at the time of the appearance of the PRSTS. RT doses ranged from 48 to 91 Gy (mean 62 Gy). The latent period from RT to the occurrence of the PRSTS varied from 4 to 27 years (mean 12.6 years). Altogether, 4 of 13 patients (31%) had recurrence of the sarcoma after resection. Of the 10 patients whose tumors were removed with a wide margin, one had a local recurrence; 3 cases were performed with a marginal margin and all 3 had a local recurrence. One of three who underwent RT and one of five who underwent chemotherapy (CT) responded. Of the 14 patients, 6 (42.9 %) survived continuously disease free, 2 (14.3%) died from other causes, 2 (14.3%) has an unknown outcome, and 4 (28.6 %) died of the disease during the follow-up period of 16-36 months (mean 24 months). The deaths due to other causes included an esophageal cancer and a wound infection. The prognosis of the PRSTS patients was not poor if the tumor could be removed with a wide surgical margin. Because adjuvant therapies including RT and CT had a poor effect on PRSTSs, the primary treatment of PRSTSs should be radical resection with a wide margin.
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PMID:Postradiation soft tissue sarcoma: a multiinstitutional analysis of 14 cases in Japan. 1516 77