Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
NPRL2
is a tumor suppressor gene whose inactivation contributes to tumor development. However,
NPRL2
expression in
osteosarcoma
remains unclear. This study aimed to assess
NPRL2
expression in
osteosarcoma
and analyze its potential as a prognostic factor.
NPRL2
expression in 48 cases of
osteosarcoma
and 40 cases of osteochondroma tumors was examined by immunohistochemistry.
NPRL2
expression in 20
osteosarcoma
and 20 osteochondroma specimens were detected by Real-time PCR and Western blot analysis. We found that 18 cases (37.5%) of
osteosarcoma
and 27 cases (67.5%) of osteochondroma showed positive
NPRL2
expression. Real-Time PCR and Western blot analysis showed that NRPL2 expression was lower in
osteosarcoma
than in osteochondroma (p< 0.05). The positive rate of
NPRL2
expression was 71.4% (10/14), 25% (4/16) and 16.7% (3/18) in stage I, II and III of
osteosarcoma
, respectively. The positive rate of
NPRL2
was 19% (4/21) and 48.1% (13/27) for low grade and high grade of
osteosarcoma
, respectively, with significant difference (p< 0.05). Cox multivariate analysis showed that the value of
NPRL2
for predicting the overall survival of
osteosarcoma
patients. Despite the small size of the samples, our results suggest that
NPRL2
expression is negatively related with the survival of
osteosarcoma
patients, indicating its value as a prognosis factor of
osteosarcoma
.
...
PMID:NPRL2 is an independent prognostic factor of osteosarcoma. 2332 67
