Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Based on the clinical evaluations about over 1800 patients who had been treated with fast neutrons at NIRS, the radiobiological properties of high LET radiations were discussed. The most favorable clinical results by fast neutron treatment had been revealed in such diseases as follows; salivary gland tumors, prostate cancer, Pancoast type lung cancer, osteosarcoma, soft tissue sarcoma. The characteristics of these tumors as to the radiobiological properties and the dose distribution are, 1) relatively slow growing tumors and higher RBE for tumor tissue, and 2) capability of correct delivery of a big radiation doses to the target, without any severe radiation complications. Normal tissue tolerance (NSD formulas) for each tissues were also discussed.
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PMID:[Normal tissue tolerance to high LET radiotherapy]. 212 4

Postradiation sarcoma is a rare late complication of external radiotherapy. We herein present two cases with this disease. A 54-year-old man had undergone a lobectomy and chest wall resection for Pancoast type lung cancer 7 years previously. He had undergone irradiation with a total dose of 50 Gy. Computed tomography (CT) demonstrated a tumorous expansion of the right lateral thoracic wall. A pathological examination confirmed a diagnosis of osteosarcoma. A 60-year-old woman had undergone a resection of the lateral chest wall mass, which was diagnosed to be Hodgkin's disease in 1991. Chemotherapy was given postoperatively. A tumorous lesion arose again and irradiation was performed with a total dose of 110 Gy. In 2000, two tumors appeared in the irradiation field. A pathological examination showed a sarcoma with divergent differentiation. In 2003, a tumor recurred and was diagnosed to be a liposarcoma. Patients who have received radiotherapy should therefore be followed up while taking into consideration the possible development of postradiation sarcoma.
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PMID:Postradiation sarcoma of the chest wall: report of two cases. 1712 40