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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bone scintigraphy with 99mTc-polyphosphate or 99mTc-pyrophosphate was carried out in 54 children suspected of bone disease. Signs of skeletal metastases were recognized in 13 children by scintigraphy whereas X-ray examination showed lesions in only 10 of these. In 5 children with primary osteosarcoma, three cases of fibrous dysplasia, and 4 cases of osteomyelitis, the lesions were clearly demonstrated by scintigraphy. Abnormal accumulation of radioactivity in soft tissue lesions was observed in primary adrenal neuroblastoma, Hodgkin's granuloma, and metastatic Burkitt's lymphoma. Several cases are reported, and the value of bone scintigraphy in children is discussed.
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PMID:Bone scintigraphy in children. 18 23

A case of an osteoblastoma of the proximal femur with a unique local, massive reactive periostitis mimicking osteosarcoma or osteomyelitis and unique systemic manifestations is reported. The severe toxic manifestations included: massive weight loss, chronic fever, anemia, systemic periostosis, and other signs. Due to confusion as to diagnosis, lack of response to numerous antibiotic regimens, and severe cachexia with clinical signs of impending death, an amputation was performed. Pathologic study revealed an osteoblastoma. A thorough review of the case suggests that the signs and symptoms were possibly consequent to an immune response mounted against the tumor rather than to secondary infection, although the latter possibility cannot be completely excluded.
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PMID:A case of osteoblastoma associated with severe systemic toxicity. 53 63

A report is drawn up of the available diagnostic procedures in the detection of the different forms of osteomyelitis. Special reference is made to the problems involved in the clinical diagnosis of the mitigated and non-typical forms of haematogenous osteomyelitis which occur more frequently in the present antibiotics era. Early diagnosis of haematogenous osteomyelitis is of the greatest importance, since, in our experience, a cure can only be expected with very early initiation of antibiotic therapy. In regard to the differential diagnosis, abortive manifestations of haematogenous osteomyelitis must be differentiated from rheumatoid arthritic diseases and soft-part inflammations of all kinds, whilst caution must be taken to avoid a mistaken diagnosis of osteosarcoma.
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PMID:[Diagnostic and differential diagnostic considerations in osteopmyelitis]. 106 87

It is often very difficult to differentiate between chronic osteomyelitis and osteogenic sarcoma which present rather similar clinical and radiological findings. In cases of doubt, the diagnosis must be confirmed by a biopsy. As therapy of chronic mandibular osteomyelitis, active surgery becomes more and more important.
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PMID:[Differential diagnosis and therapy of chronic mandibular osteomyelitis]. 106 82

We report the case of a young boy referred to our Department of Nuclear Medicine under the suspicion of a malignant tumor. The leading clinical symptoms were pain in the joints and loss of weight and vitality. Radiographic findings were suggestive of osteogenic sarcoma, but bone scans showed multiple increased tracer depositions along the cortex of femur and tibia, and in the lower and upper jaw. The enrichment pattern was not typical for metastases, but more probably demonstrated the multiple foci of osteomyelitis. This assumption was confirmed by the histological findings, which were diagnosed as primary chronic osteomyelitis. This rare pediatric bone disorder has been described by Giedion et al. The etiology of the disease is unknown, and therapy is discussed controversely in literature.
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PMID:Case report 756: Chronic multifocal osteomyelitis. 143 3

MRI can yield valuable information about involvement of bone and soft tissue by aggressive bone lesions of childhood. The 18 lesions evaluated with MRI included osteosarcoma, Ewing's sarcoma, histiocytosis, osteomyelitis, osteoblastoma, giant cell tumor, aneurysmal bone cyst, ossifying fibroma, and fibrous dysplasia. In 12 children, where CT correlation was available, MRI provided equal or more information than CT. Our study shows that MRI should be the modality of choice in the evaluation of aggressive bone lesions of childhood, after conventional radiography.
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PMID:MRI of aggressive bone lesions of childhood. 154 87

Eighteen cases of osteogenic sarcoma of the long bones in the extremities were analyzed in this paper. The pathological basis of the X-ray signs was explained. It was suggested that solitary calcific shadow appearing near the knee joint in young individuals should alert the radiologist to the possibility of osteogenic sarcoma. The X-ray findings of osteogenic sarcoma were characterized by dissociation of osteolysis from ossification. Simultaneous bony destruction both inside and outside the cortex was one of the patterns of erosive bone destruction in osteogenic sarcoma. The distinction between benign and malignant bony spicules, the differences in the relationship between soft tissue mass and subcutaneous fat layer and that between osteomyelitis and the subcutaneous fat layer were discussed.
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PMID:[Osteogenic sarcoma (report of 18 cases)]. 262 6

In spite of the fact that the first description of stress fracture appeared 130 years ago, its origins still remain unknown. There are numerous potential factors causing fractures in some circumstances. It is sure that this is the result of disharmony of overstrain (bending force or compression force) of groups of muscles on the one hand and skeletal carrying capacity, i. e. one skeletal segment on the other hand. In differential diagnosis, particular attention is to be paid to some localizations, firstly to tibia and femur, since sometimes they are similar to osteomyelitis, osteoid-osteoma or osteogenic sarcoma. It may be supposed that the number of cases constantly grows, corresponding to higher number of participants of various sports and of different age, to be determined by the application of new diagnostic methods, revealing the development of the process far earlier than x-ray (scintiphotography, thermography, ultrasonography and CT). The majority of cases are successfully treated and cured by conservative methods, frequently only by resting, while only rarely there are cases with shift of segments and indicated surgical treatment. A lot of cases are asymptomatic. In the period from 1981 to 1986, we clinically registered 113 cases of stress fractures with soldiers, 105 of them of metatarsus bones, 4 of tibia, 3 of fibular malleolus and 1 of cuboid bone.
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PMID:[Stress fractures]. 279 82

A 46-month-old boy with a four-day history of pain and swelling over the right posterior ilium was thought to have acute osteomyelitis on the basis of a normal pelvic x-ray, markedly increased scintigraphic activity in the right ilium, and a mildly elevated sedimentation rate. At surgery, no signs of osteomyelitis were found, and biopsy revealed osteolytic osteogenic sarcoma. This is the youngest child with osteogenic sarcoma of the pelvic reported in the literature.
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PMID:Osteolytic osteogenic sarcoma of ilium in 46-month-old boy. 348 37

The diagnosis of osteomyelitis is usually clear by a constellation of clinical, radiographic, and/or scintigraphic findings. Computed tomography may be used to clarify the nature of a bony process. In addition to the CT findings already described, an additional finding is reported, consisting of the visualization of a small sequestrum. This finding has to be differentiated from the similar appearance in osteoid osteoma, intraosseous lipoma, fibrous dysplasia, and osteogenic sarcoma.
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PMID:Visualization of small sequestra by computerized tomography. Report of 6 cases. 387 39


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