Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
p21-activated kinase 7
(
PAK7
), also named as PAK5, is a member of Rac/Cdc42-associated Ser/Thr protein kinases. It is overexpressed in some types of cancer such as colorectal and pancreatic cancers. However, the expression status and biological function of
PAK7
in
osteosarcoma
are still ambiguous. To evaluate the expression levels of
PAK7
in
osteosarcoma
tissues and cell lines, immunohistochemistry was used. To investigate the role of
PAK7
in cell proliferation, apoptosis and tumorigenicity in vitro and vivo, a recombinant lentivirus expressing
PAK7
short hairpin RNA (Lv-shPAK7) was developed and transfected into Saos-2 cells. The silencing effect of
PAK7
was confirmed by quantitative real-time PCR (qRT-PCR) and Western blot technique.
PAK7
was overexpressed in
osteosarcoma
tissue and cell line. By knocking-down of
PAK7
, the proliferation and colony formation of Saos-2 cells were inhibited and apoptosis enhanced significantly. The in vivo tumorigenic ability in xenograft model of Saos-2 cells was also notably inhibited when
PAK7
was knocked down. Our results imply that
PAK7
promotes cell proliferation and tumorigenesis and may be an attractive candidate for the therapeutic target of
osteosarcoma
.
...
PMID:p21-activated kinase 7 is an oncogene in human osteosarcoma. 2505 21
