Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acquired von Willebrand disease is likely underdiagnosed due to the clinical variability in presentation and variety of conditions, including lymphoproliferative and myeloproliferative syndromes, autoimmunity, solid tumors, hypothyroidism, and cardiovascular disease, in which it can present. Pediatric patients with Wilms tumor have been reported in the literature with acquired von Willebrand disease and it has been theorized to occur in other pediatric solid tumors. Here we present the first reported case of acquired von Willebrand disease secondary to osteosarcoma in an adolescent patient, resolving spontaneously with treatment of her underlying disease.
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PMID:Acquired von Willebrand disease in an osteosarcoma patient. 2204 79

A 63-year-old man presented with sexual dysfunction of 6-year duration, 5-year history of bilateral vision loss, and left nasal obstruction for 3 years. Brain computed tomography and magnetic resonance imaging showed a large mass lesion in the saddle area and extending upward to the dorsum sellae, bilateral cavernous sinus, and suprasellar region, and down into the sphenoid sinus and nasal cavity; the optic nerves and optic chiasm were elevated upward and compressed. Endocrine tests indicated that all serum level of anterior pituitary hormones decreased. The preoperative diagnosis included invasive pituitary adenoma, chordoma, osteosarcoma, chondrosarcoma, and craniopharyngioma. The tumour was subtotally removed through transsphenoidal approach. Histopathology examination revealed a chondroma. Postoperatively, the patient was stable and his visual acuity and visual field defect improved and his pituitary function return to normal except for hypothyroidism.
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PMID:Giant Chondroma of the Saddle Area: Case Report and Literature Review. 2816 92