Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Giant-cell tumor of the jaw presents difficulty in diagnosis. It is rare in the head and neck regions and may resemble, clinically and histologically, other types of jaw lesion. However, histologic study may distinguish this lesion from a giant-cell granuloma, an osteogenic sarcoma, and most epulides. Adequate surgical excision with a long-term follow-up is the recommended treatment of choice.
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PMID:Giant-cell tumor of the maxilla. Report of a case. 28 40

Ultrasonic velocity and attenuation are determined in different types of bone tumors by using a double-probe-through-transmission ultrasonic technique. The average values of propagation velocity in different types of tumors are found as 2106, 2304, 2677.5, and 3586 m/s with 1.49%, 1.04%, and 0.74% standard deviation in Giant Cell, Lymphoma, Chondro Sarcoma, and Osteogenic Sarcoma, respectively. Absorption coefficient of ultrasound is found to be minimum as 19.7 dB/cm with 0.002% standard deviation in Lymphoma, and high in Osteochondroma and not measurable with the present setup. A direct technique for the diagnosis and differentiation of various types of tumors can be developed by standardization of the data.
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PMID:Measurement of ultrasonic velocity and attenuation in bone tumors, in vitro. 240 61

In osteoclastic giant cells of six different tumors of bones and joints (fibrous dysplasia, proliferating giant cell tumor, malignant giant cell tumor, osteosarcoma after chemotherapy, malignant synovioma and Ewing's sarcoma) activities of tartrate-resistant acid phosphatase, NADH-tetrazolium-oxidoreductase and, in three of them, of non-specific esterase are determined by enzyme histochemical methods. Quantitative microphotometry makes it possible to determine relative enzyme activities in the cut sections of giant cells of different sizes. Giant cells of the various tumors reveal similar trends: With an increase in cell size, mean extinctions of NADH-tetrazolium-oxidoreductase and non-specific esterase decrease. Mean extinctions of tartrate-resistant acid phosphatase increase in cells of medium size, whereas the large cells reveal in part low activities. An additional ultrastructural examination of the giant cells in the proliferating giant cell tumor as well as in the osteosarcoma shows morphological signs of degeneration in the large cells. Electron probe microanalysis of the proliferating giant cell tumor exhibits evidence of phagocytosis of Ca and/or Fe containing particles. The similar size dependent reaction pattern of enzymes in osteoclastic giant cells of different tumors favors the concept of a common histogenesis, i.e. a host reaction.
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PMID:Size dependent enzyme activities of multinucleated (osteoclastic) giant cells in bone tumors. 303 7

A microspectrophotometric study of DNA content was carried out on cells from three types of bone tumor--osteoclastoma, chondroblastoma, and osteosarcoma--in all of which the formation of multinucleated giant cells occurs. Giant cells of osteoclastic type were present in all the tumors, with contents of DNA which were constant, uniform and diploid in character for each nucleus individually considered. Since there were no nuclei with reduced or increased content of DNA, mitotic proliferation or gemmation can be excluded. Instead, the evidence suggests the formation of giant cells through a mechanism of cellular fusion. In contrast, the stromal cells of the osteoclastomas and the chondroblastomas gave evidence of DNA synthesis, thus proving their proliferative capacity in both tumors. The osteosarcomas showed a very irregular distribution of DNA, and generally the nuclear content of DNA exceeded the diploid DNA content.
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PMID:Microspectrophotometric quantitation of DNA in bone tumors with giant cells (osteoclastoma, osteosarcoma and chondroblastoma). 693 15

The purpose of this report is to describe giant solitary synovial chondromatosis, a previously unrecognized feature of synovial chondromatosis that may histologically and radiographically mimic a malignant neoplasm. Giant solitary synovial chondroma is an intra- and/or extraarticular lesion measuring over 1 cm in size and sometimes as large as 20 cm. The radiographic appearance is that of a large, well-marginated mass either of irregular feathery calcification from coalescence of multiple small synovial chondromas, or a rounded calcified mass from the growth of a single synovial chondroma. Radiographically, giant solitary synovial chondromatosis may appear similar to chondrosarcoma and parosteal osteosarcoma.
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PMID:Giant solitary synovial chondromatosis. 816 32

Photodynamic therapy is a tumoricidal modality that utilizes an inactive pharmacologic agent that becomes activated on exposure to visible light. Neoplasms selectively retain and accumulate photosensitizers at levels generally higher than surrounding non-neoplastic tissues. The purpose of this study was to establish a testing method for in vitro investigation of the effects of photodynamic therapy on human musculoskeletal neoplasms by examination of the sensitivity of these tumors to photoactivation. Three human musculoskeletal neoplasms were cultured, exposed to the photosensitizer Photofrin, and then studied for their response to photodynamic therapy after laser activation. Giant-cell tumor, dedifferentiated chondrosarcoma, and osteosarcoma were examined with use of strict experimental controls. The photoradiation conditions during photodynamic therapy were kept constant. Cell viability was determined as a function of energy dose. We concluded that the three musculoskeletal tumors were susceptible to in vitro photodynamic therapy and the test system was reproducible. The optimal in vitro nontoxic incubation concentration of Photofrin was 3 micrograms/ml. A differential cytotoxic response to photodynamic therapy was exhibited by the musculoskeletal neoplasms as a function of increased dosages of energy.
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PMID:In vitro photodynamic therapy of musculoskeletal neoplasms. 841 Apr 62

Osteoclast-like giant cells (GC) may dominate the histologic pattern not only in conventional giant-cell tumor (GCT)--originating as a radiologically pure lytic, possibly trabeculated lesion especially within the epiphyses of long tubular bones (LB) and pelvic bones of adults--but also in many tumor-like lesions as well as in various benign and malignant bone tumors which may simulate each other. Although the mononuclear cells as well as the amount of collagene fibres don't differ significantly, these lesions can be distinguished by substantial differences concerning their site, radiomorphology and the patients age. The unique lesion which can be recognized by histology only is chondroblastoma--centered in epiphyseal regions as GCT, mostly in the 2nd decade--by its typical mononuclear cells independently of the typical chondroid matrix and calcifications. The brown tumor of hyperparathyreoidism is associated with elevated serum Ca and parathormon, which is not altered in the histologically identical giant cell granuloma. In contrast to GCT aneurysmal bone cyst prefers the metaphyseal area of LB and the posterior parts of vertebras in the 2nd decade. Metaphyseal fibrous defects occurring during growth period leave the epiphyses unaffected and display typical x-rays. Villondoular synovitis sometimes can produce osteolytic defects. GC-rich malignant tumors which present with clear cut atypia except some cases of GC-variants of osteosarcoma, are: Giant-cell rich osteosarcoma, the rare malignant GCT, giant-cell ("osteoclastic") sarcoma, MFH and GC-rich metastases of carcinomas. All of them occur in middle aged and older patients except osteosarcoma and don't affect the epiphyses primarily except malignant GCT. To avoid confusion in GC-lesions it is conditio sine qua non to take into account for diagnosis not only histology but especially radiomorphology as well as site of the lesion and patients age.
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PMID:[Differential diagnosis of giant cell tumor of bone]. 1009 27

A retrospective study of the pattern of bone tumours over a 6-year period at the National Orthopaedic Hospital, Lagos, Nigeria, has been done. Only those patients with histological diagnosis of bone tumours had their medical records analysed. Thirty-six cases were seen with 19 males and 17 females. The benign cases numbered 24, while malignant cases numbered 12. Osteochondroma and Giant Cell Tumour, numbering 14 and 5 respectively, were the commonest benign lesions, while osteosarcoma numbering 8 cases, was the commonest malignant lesion. The age and sex patterns conform with worldwide patterns. The usual presenting symptoms was mass/swelling with or without pain. The benign cases had excision plus/minus bone grafting of their lesions while some of the malignant cases had ablation before referral to the radiotherapist at the Lagos University Teaching Hospital (LUTH). The treatment outcome could not be verified due to poor follow-up of most cases.
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PMID:Pattern of bone tumours at the National Orthopaedic Hospital, Lagos, Nigeria. 1176 18

We report a case of giant cell-rich osteosarcoma in the right distal femur of a 32-year-old man. Giant cell-rich osteosarcomas are sometimes difficult to distinguish from giant cell tumors by age, location, magnetic resonance imaging findings, and pathology. Radiography may be useful in the diagnosis of giant cell-rich osteosarcoma.
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PMID:Giant cell-rich osteosarcoma of the distal femur: radiographic and magnetic resonance imaging findings. 1687 13

Giant cell-rich osteosarcoma (GCRO) is a rare subtype of osteosarcoma, and no literature has reported occurrence in the mandible region up to now. In this article, we report a case of GCRO originating from the mandible in a 67-year-old woman who presented a history of painless mass located in the left side of the mandible after teeth extraction. The curettage biopsy histologic diagnosis is giant cell reparative granuloma before mandibulectomy surgery, but panoramic radiograph revealed an osteolytic lesion. The tumor was completely resected with segmental mandibulectomy and soft tissue with postoperative histologic diagnosis of GCRO. The free fibula osteomyocutaneous flap was performed to reconstruct the defect of the mandible and gingival mucosa. The patient received postoperative radiotherapy and chemotherapy. The 1-year follow-up situation is fine.
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PMID:Giant cell-rich osteosarcoma or giant cell reparative granuloma of the mandible? 2158 69


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