Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An
osteogenic sarcoma
of the tibia occurred in an eight-year-old boy with
epidermolysis bullosa
dystrophica hereditaria (EBDH) (Hallopeau-Siemens type). The patient had had the congenital skin disease since the time of birth. A painful swelling appeared in the proximal portion of his right tibia, which was diagnosed as
osteogenic sarcoma
on biopsy study. The patient died of massive pulmonary metastases and cachexia four months after the onset of the tumor.
Osteogenic sarcoma
in a patient with EBDH seems not to have been previously reported. EBDH has been known to be occasionally associated with squamous cell carcinoma. Whether an impairment of the patient's defense mechanism by the chronic skin disease might have enhanced the rapid progression of the associated bone malignancy is unknown.
...
PMID:Osteogenic sarcoma of the tibia in a patient with epidermolysis bullosa dystrophica. 342 8
