Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new avian transforming retrovirus, NK24, was isolated from a chicken with a nephroblastoma. This transforming virus induced fibrosarcomas with osteogenic cell proliferation and nephroblastomas in vivo and transformed fibroblast cells in vitro. From extracts of NK24-transformed cells, anti-gag serum immunoprecipitated a 100-kilodalton nonglycosylated protein with no detectable protein kinase activity. An NK24 provirus present in infected quail cells was molecularly cloned and subjected to nucleotide sequence analysis. The genome of NK24 was 5.3 kilobases long and had a 1,126-base-pair sequence of cellular origin in place of a viral sequence of avian leukosis virus containing the 3' half of the gag gene and the 5' half of the pol gene. Although the entire env gene was retained, it appeared to be inactive, possibly owing to the loss of function of its splice acceptor site as a result of a second deletion of 1,598 bases in the 3' half of the pol gene that extended to the acceptor site. Nucleotide sequence analysis revealed that the NK24 virus contained the fos gene, previously identified as the oncogene of FBJ and FBR murine osteosarcoma viruses. Unlike the v-fos gene products of FBJ and FBR, which suffer a structural alteration at their carboxyl termini, the NK24 v-fos gene product seemed to have the same carboxyl-terminal structure as the chicken c-fos gene product. A comparison of the structures of the products of the NK24 v-fos and mouse c-fos genes suggested that the fos gene product consists of highly conserved regions and relatively divergent regions.
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PMID:An avian transforming retrovirus isolated from a nephroblastoma that carries the fos gene as the oncogene. 282 11

In human immunodeficiency virus type 1-infected cells, the efficient expression of viral proteins from unspliced and singly spliced RNAs is dependent on two factors: the presence in the cell of the viral protein Rev and the presence in the viral RNA of the Rev-responsive element (RRE). We show here that the HIV-1 Rev/RRE system can increase the expression of avian leukosis virus (ALV) structural proteins in mammalian cells (D-17 canine osteosarcoma) and promote the release of mature ALV virions from these cells. In this system, the Rev/RRE interaction appears to facilitate the export of full-length unspliced ALV RNA from the nucleus to the cytoplasm, allowing increased production of the ALV structural proteins. Gag protein is produced in the cytoplasm of the ALV-transfected cells even in the absence of a Rev/RRE interaction. However, a functional Rev/RRE interaction increases the amount of Gag present intracellularly and, more strikingly, results in the release of mature ALV particles into the supernatant. RCAS virus containing an RRE is replication-competent in chicken embryo fibroblasts; however, we have been unable to determine whether the particles produced in D-17 cells are as infectious as the particles produced in chicken embryo fibroblasts.
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PMID:Production of avian leukosis virus particles in mammalian cells can be mediated by the interaction of the human immunodeficiency virus protein Rev and the Rev-responsive element. 852 79

In the 10 years to November 1987, 33 different types of naturally occurring neoplasms were diagnosed in 2281 domestic fowls submitted for necropsy examination. The most prevalent type was lymphoma (1825/2281 = 80%) including two cases in chickens from a flock free from Marek's disease virus, exogenous avian leukosis viruses and reticuloendotheliosis virus; the remaining lymphomas were diagnosed on gross and/or histological criteria as Marek's disease (1069) or lymphoid leukosis (754). Of the non-lymphoid neoplasms, leiomyomas of the ventral ligament of the oviduct (99) were the most common followed closely by metastatic abdominal adenocarcinomas (93) and haemangiomas or haemangiosarcomas (91). A large number of fibromas and fibrosarcomas (40), and a smaller number of myxomas and myxosarcomas (17) were observed. Three fibrosarcomas and two myxosarcomas were presented as metastatic abdominal neoplasms, and two fibromas and seven myxomas were found on the rostral extremity of the upper beak of hens, including five cases of myxoma from one flock. Other less prevalent neoplasms described were myelocytomas or myeloblastomas (12), avian keratoacanthomas (11), granulosa-theca cell tumours (11), oviduct adenomatosis and adenocarcinomas (10) and ovarian adenocarcinomas (8). Small numbers of some neoplasms or well-characterized variants were encountered, namely histiocytic sarcomas (5), lipomas (4), liposarcomas (2), reticulum cell sarcomas (3), plasmacytomas (3), intracutaneous keratinizing epitheliomas (3), feather folliculomas (2), proventricular adenomas (2), hepatocellular adenocarcinomas (2), cholangiocellular adenomas and adenocarcinomas (6), pancreatic adenocarcinomas (3), nephroblastomas (7), astrocytomas (5), pinealomas (3), Schwannomas (3) and multifocal melanomas (3). Single examples were found of osteoma, osteosarcoma, rhabdomyosarcoma, leiomyoma of the gizzard wall, intestinal adenocarcinoma, renal adenocarcinoma, adrenocortical adenoma and ultimobranchial cyst.
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PMID:Some observations on naturally occurring neoplasms of domestic fowls in the State of Victoria, Australia (1977-87). 1864 70