Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Reconstruction after resection of tumor about the acetabulum represents a considerable challenge in reconstructive surgery. Between 1999 and 2003, three patients with periacetabular tumors underwent tumor resections (Ennecking type B) and pelvic ring reconstruction with microsurgical fibular flaps. Histological diagnosis showed osteosarcoma, giant cell tumor, and aneurysmoid bone cyst. All patients survived surgery without complications. The follow-up for patients ranged from 14 to 42 months. The average time for bone healing and full weight bearing was 13.6 weeks after surgery. In evaluations of the functional outcome using Enneking scoring system, two reached the score of excellent (>or= 23 points), and one reached the score of good (15 to 22 points). This report shows our experience in use of microsurgical fibular flaps for arthrodesis of the hip after periacetabular tumor resection, which restores the continuity of the pelvic ring with minimal shortening of the limb.
 ...
PMID:Microsurgical fibular flap for pelvic ring reconstruction after periacetabular tumor resection. 1747 51

A consecutive series of cases of dogs and cats with locked jaw syndrome (inability to open or close the mouth) are reported in this study. Dogs were significantly overrepresented (84.0%) and adult dogs were more frequently affected (81.0%). Temporomandibular joint ankylosis due to fracture was the most common cause (54.0%) of locked jaw syndrome. Additional potential causes of locked jaw syndrome are masticatory muscle myositis, neoplasia, trigeminal nerve paralysis and central neurological lesions, temporomandibular joint luxation and dysplasia, osteoarthritis, retrobulbar abscess, tetanus, and severe ear disease. Treatment of locked jaw is directed towards the primary cause. It is important to treat the tonic spasm in order to minimize periarticular fibrosis. Surgical intervention is recommended for temporomandibular joint ankylosis. Masticatory muscle myositis treatment is initiated by gradually opening the mouth, with medical treatment based on immunosuppressive therapy. Fracture and masticatory muscle myositis are associated with a relatively good prognosis in regard to short-term outcome as compared to animals with central neurologic lesions or osteosarcoma which have a poor prognosis.
 ...
PMID:Locked jaw syndrome in dogs and cats: 37 cases (1998-2005). 1875 57

The predominant tumour of the pelvic region in children and adolescents is Ewing's sarcoma followed by osteosarcoma. Both tumours are treated by chemotherapy and the best chance of survival is offered by wide tumour resection. Compared to surgical treatment on the extremities, the resection and reconstruction of pelvic sarcomas remains challenging. Surgery of pelvic sarcomas shows higher rates of local recurrence and complications and a lower functional outcome than other localisations. Especially in children and adolescents the reconstruction methods have to focus additionally on the growing skeleton. According to the different types of pelvic resections and therefore the need of different reconstruction methods, the following article is based on Enneking's surgical classification of pelvic resections. Type I resections are best reconstructed with autografts implanted between the supracetabular osteotomy and the sacrum. Patients show the best functional results after this reconstruction. Periacetabular resections (type II) in small children do best with iliofemoral arthrodesis or pseudarthrosis; in larger adolescents the use of the pedestal Schoellner cup showed superior results over the prior saddle prosthesis. Type III resections are not reconstructed. Complete internal hemipelvectomy represents the most difficult situation, in children as well as in adults. High complication rates after allograft and endoprosthetic reconstruction have recently favoured the renaissance of a flail hip reconstruction or the hip transpositionplasty.
 ...
PMID:Reconstruction of the pelvis after resection of malignant bone tumours in children and adolescents. 1923 May 37

Osteosarcoma rarely occurs in the patella. The majority of lesions located in the patella are usually benign. According to the literature, osteosarcoma of the patella has been reported in 32 cases. Surgical treatment (patellectomy, resection and arthrodesis with allograft, and total joint replacement) was attempted in several cases, but neither function of the knee joint nor prognosis of the patients were good. A 53-year-old woman reported pain and swelling in the left knee. Based on plain radiographs and magnetic resonance imaging (MRI), a bone tumor was suspected, and an open bone biopsy of the patella was performed. The pathologic diagnosis was osteoblastic osteosarcoma. A total patellectomy was performed because MRI showed a lesion that did not spread into the joint. A reconstruction was subsequently performed by allograft patella. The graft consisted of a quadriceps tendon, a patella with a patellar tendon, and the medial and lateral retinacula. Twenty-six months postoperatively, the function of the knee joint was almost similar to that before the procedure, and there was no evidence of recurrence or metastasis. After the procedure, the patient could walk without pain and the knee joint could flex to 140 degrees with extension lag of 10 degrees . To our knowledge, this is the first report of a biologic reconstruction with allograft patella after total patellectomy in osteosarcoma involving the patella.
 ...
PMID:Osteosarcoma of the patella: biologic reconstruction with allograft. 1982 94

Bone and soft tissue malignancies are associated with serious diagnostic and therapeutic problems in every level of pubertal growth in children. Current treatment modality preferred in bone and soft tissue tumors is wide resection of tumor followed by the reconstruction of consequent defect by various methods. Chemotherapy and radiotherapy are applied for systemic effects to the patient pre- and post-operatively and for local effects that facilitate the surgical procedure. Mostly, it is very difficult to control problems following wide resection and reconstruction. In this study, our aim is to discuss the problems encountered in different resection and reconstruction approaches in childhood bone and soft tissue tumors, and the recommended solutions addressed to these problems. From 1990 to 2003, a total of 68 patients (38 female, 30 male) with a mean age of 13.1 (1.5-18) were included in the study. 85.3% of patients were diagnosed as osteosarcoma and the rest was Ewing's sarcoma. Seventy-five percent of patients had stage IIB disease. The lesions of 34 patients were detected to be in distal femur, 26 in proximal tibia and fibula, 4 in foot and ankle joint, and the remaining 4 in pelvis. As reconstructive surgery, 40 patients had modular prosthesis, vascularized fibular graft was performed in 13 patients, and 10 patients underwent arthrodesis with vascularized fibular graft. 20.6% of patients had shortened limb, infection was detected in 4 patients, laxity in 5, and restricted motion in 4 as complication of prosthesis. With sacrificed physis, 13 patients had a mean value of 4.6 cm limb shortness. Limb salvage surgery has been considered as the gold standard treatment in orthopedic oncological surgery. More understanding of the biology of sarcoma, introduction of new effective chemotherapeutic agents, development of new techniques concerning the surgical resection, advances in diagnostic methods, and improvements in reconstructive surgery all make a major contribution to limb salvage surgery. Since some problems are still encountered, we offer a therapeutic algorithm for complications in the management of childhood tumors that we have encountered so far.
 ...
PMID:Complications of limb salvage surgery in childhood tumors and recommended solutions. 1995 10

We report the results of wide local excision of stage II8 proximal humeral tumors followed by reconstruction with parallel nonvascularized fibular bone grafts in three patients. Mean follow-up was 5 years (range 3 years to 8 years, 6 months). The pathologic diagnosis was osteogenic sarcoma in two patients and Ewing's sarcoma in one. The rotator cuff and deltoid were excised to achieve a wide margin around these tumors. All patients remain free from disease. They were able to return to previous work and sport activities. Two had a fracture of the graft; one fell from a mountain bike and the other fell at work. The former fracture united; the latter fracture required fixation and bone grafting to achieve union. By Enneking's 30-point functional evaluation, all three patients were in the excellent category with scores of 25, 26, and 28. We conclude that for the treatment of malignant tumors of the shoulder region with muscle involvement, excision followed by arthrodesis with parallel autogenous fibular bone grafts provides a method of retaining satisfactory upper limb function and acceptable cosmesis.
 ...
PMID:Resection arthrodesis of the shoulder with autogenous fibular bone grafts. 2295 92

The treatment and outcome of two patients suffering from osteosarcoma of the lower extremity evolving many years after manifestation of chronic osteomyelitis are reported. After neoadjuvant polychemotherapy in one patient en bloc resection, interposition of a cement spacer and stabilization was performed in both cases. After eradication of infections final segmental reconstruction was accomplished by knee arthrodesis using rotation plasty of the split femoral condyle, free local fibula transposition and gastrocnemius muscle transfer. A custom-made diaphyseal replacement (3D-rapid prototyping titanium mesh) was used for defect reconstruction. After 1 year postoperative follow-up and restaging both patients showed no evidence of recurrent disease and had no local or systemic signs of infection.
...
PMID:[Manifestation of osteosarcoma of chronic osteomyelitis: 2 case reports]. 2346 13

This report describes limb-sparing surgery in a 35 kg, six-year-old Hungarian Vizsla with a distal radial lytic bone lesion. Preoperative biopsy had suggested a bone cyst, however histopathology on the excised bone segment was indicative of an osteosarcoma. Following excision of the tumour, the bone defect was filled with a composite bone graft and stabilized with a custom-made dorsal 3.5/2.7 mm pancarpal arthrodesis plate and an orthogonally positioned medial 2.7 mm compression plate. This technique has not previously been described for limb-sparing procedures. No complications were encountered, and despite the owners declining adjunctive chemotherapy, the dog was alive 34 months postoperatively with near normal limb function.
...
PMID:Orthogonal bone plate stabilization for limb-sparing surgery. 2408 86

Sixteen patients (11 men and 5 women), who formed the basis of the study, underwent surgery in the Hand and Reconstruction Microsurgical Unit, Orthopedic Department, Sohag Faculty of Medicine, from January 2001 to January 2009.The right side was involved in 7 cases and the left side in 9 cases. Average age was 35.2 years. The causes of bone defects were infected nonunion of both bone forearms in 5 cases, infected nonunion of the middle part of radius in 4 cases, posttraumatic bone loss of distal radius in 4 cases, and tumor of shaft humerus in 3 cases (aneurysmal bone cyst in 1 and osteosarcoma in 2 patients).The principle of treatment was debridement and excision of either infected unhealthy bone or tumor tissues with wide safety margin.The average bone defect was 8 cm (range, 6-14 cm). The defect was bridged by osteoseptocutaneous vascularized fibular bone graft. The donor bone was the right fibula in 7 cases and the left fibula in 10 cases. Two grafts were used in 1 patient because of soft tissue injuries, which included the peroneal vessels during osteotomy. The vascularized fibula was fixed by small dynamic compression plate. The operative time ranged between 7 and 11 hours. Blood transfusion was indicated in all the cases and its average transfusion was 1000 mL. The average follow-up was 84 months. Bone union was ultimately obtained in 15 patients except 1 who had failure of the graft. Arthrodesis of the distal ulna with the wrist joint was done during the follow-up. Arthrodesis of the wrist joint was also performed for 1 patient who had loss of carpal bones, distal radius, and wrist and finger extensors. The average time for union was 3.5 months. The hand function was normal in all cases. Stress fracture and fibular donor-site morbidity did not occur in this series. Neither shoulders nor elbows were affected postoperatively. There was no recurrence for either infection or tumor.
...
PMID:Management of upper limb bone defects using free vascularized osteoseptocutaneous fibular bone graft. 2412 38

The three more frequent primitive malignant bone tumour which concerned the iliac bone are chondrosarcoma, following Ewing sarcoma and osteosarcoma. Wide resection remains the most important part of the treatment associated with chemotherapy for osteosarcoma and the Ewing sarcoma. Iliac wing resections and obdurate ring don't required reconstruction. However, acetabular resections and iliac wing resection with disruption of the pelvic ring required reconstruction to provide acceptable functional result. Acetabular reconstruction remains high technical demanding challenge. After isolated acetabular resection or associated to obdurate ring, our usual method of reconstruction is homolateral proximal femoral autograft and total hip prosthesis but it is possible to also used : saddle prosthesis, Mac Minn prosthesis with auto or allograft, modular prosthesis or custom made prosthesis, massive allograft with or without prosthesis and femoro-ilac arthrodesis. After resection of the iliac wing plus acetabulum, reconstruction can be performed by femoro-obturatrice and femora-sacral arthrodesis, homolateral proximal femoral autograft and prosthesis, femoral medialisation, massive allograft and massive allograft. Carcinological results are lesser than resection for distal limb tumor, local recurrence rate range 17 to 45%. Functional results after Iliac wing and obdurate ring are good. However, acetabular reconstruction provide uncertain functional results. The lesser results arrive after hemipelvic or acetabular and iliac wing resection-reconstruction, especially when gluteus muscles were also resected. The most favourable results arrive after isolated acetabular or acetabular plus obturateur ring resection-reconstruction.
 ...
PMID:[Pelvic reconstructions after bone tumor resection]. 2456 77


<< Previous 1 2 3 4 5 Next >>