Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029463 (osteosarcoma)
 16,637 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 19-year-old woman with a diagnosis of osteosarcoma was initially treated with amputation of her right leg and adjuvant adriamycin. She developed pulmonary metastases 18 months following diagnosis. She was then given cis-dichlorodiammineplatinum(II) (DDP) at a dose of 100 mg/m2 iv approximately every 4 weeks as the sole drug. Following the fifth dose of DDP, she complained of numbness and tingling in her hands and leg. A distal sensory loss extending to both elbows and her remaining knee was found on examination. Nerve conduction tests were compatible with peripheral neuropathy of the "glove and stocking" type. DDP was withheld and her sensory loss improved over the next 2 months, but became worse after another course of DDP was administered. The temporal relationship between the findings and the administration of DDP implicates this drug as the causative agent in the peripheral neuropathy.
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PMID:Peripheral neuropathy as a complication of cis-dichlorodiammineplatinum(II) treatment: a case report. 20 27

The authors report a case of radiation-induced calvarial osteosarcoma. A 58-year-old female received subtotal removal of the pituitary adenoma and 5000 rads postoperative irradiation. Seven years later, an osteoblastic osteosarcoma occurred in the frontotemporal region. She received total tumor removal and chemotherapy. However, computed tomography subsequently revealed multiple small lesions at the margin of the bone flap. A chest x-ray film demonstrated lung metastasis. Local recurrence and lung metastasis require careful attention in radiation-induced osteosarcoma patients.
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PMID:Radiation-induced osteosarcoma of the calvaria--case report. 137 83

Clostridium difficile-associated diarrhea (CDAD) is caused by a toxin elaborated by the anaerobic organism Clostridium difficile. Although the vast majority of CDAD cases are now associated with antibiotic use, the administration of antineoplastic agents alone can result in clinical manifestations. While therapy with oral vancomycin is usually successful, one quarter of patients will relapse. We describe a 16-year-old girl with osteogenic sarcoma whose therapy was significantly complicated by multiple relapses of CDAD. All resulted in hospital admission. She failed several standard therapies for relapsed CDAD and was cured only after prolonged cholestyramine therapy. A subset of multiply relapsed CDAD patients may require prolonged therapy with cholestyramine to control the disease.
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PMID:Multiple relapses of Clostridium difficile-associated diarrhea in a cancer patient. Successful control with long-term cholestyramine therapy. 145 3

A 24-year-old patient who developed breast cancer 16 years after chemotherapy for osteosarcoma is presented. She had no family history of cancer. She had also not had radiotherapy. She had been given chemotherapy consisting of VAOMT (vincristine 10.2 mg, cyclophosphamide 900 mg, mitomycin C 15.2 mg, chromomycin A3 25.8 mg) pre- and post-operatively in the treatment of her osteosarcoma. Careful long-term follow-up is required after treatment of malignant neoplasms because there is a possibility of developing a second malignancy.
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PMID:Breast cancer developing after chemotherapy for osteosarcoma: a case report. 166 61

A 12-year-old girl with nonmetastatic osteogenic sarcoma received treatment with doxorubicin, methotrexate, cisplatin, cyclophosphamide, bleomycin, and dactinomycin. She developed unexplained persistent pancytopenia after completion of chemotherapy. Twenty-three months after the initial diagnosis of osteosarcoma an evaluation revealed a bone marrow pattern consistent with the diagnosis of refractory anemia with excess blasts, and karyotype analysis showed characteristic findings of therapy-related myelodysplasia (loss of chromosomes 5 and 7, as well as 12p and 17p deletions). Bone marrow transplantation from an human leukocyte antigen (HLA)-compatible sibling donor was performed 26 months after the diagnosis of the primary malignancy. Although it is unproven that the alkylating agents administered to this patient were responsible for the myelodysplastic syndrome, careful follow-up of osteosarcoma patients who receive alkylating agents is warranted.
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PMID:Secondary myelodysplastic syndrome complicating therapy for osteogenic sarcoma. 171 91

The case of a patient with postirradiation osteosarcoma is presented. The 20-year-old female was diagnosed as having osteosarcoma by histological examination of an open biopsy specimen. She underwent surgery for pure dysgerminoma and received adjuvant postoperative radiotherapy, 40 Gy to the pelvis and 30 Gy to the para-aortic region, 11 years ago. This case satisfied the criteria for radiation-induced osteosarcoma proposed by Cahan et al. Radiation-induced osteosarcoma is rare, but the possibility of that must be borne in mind.
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PMID:Osteosarcoma following radiotherapy: a case report. 177 Dec 48

The roentgen findings of 17 cases of parosteal osteosarcoma were analyzed. In 13 of them, a patho-radiologic correlative study was conducted. The results showed that there was an obvious relationship between the radiologic pattern and the degree of malignancy. On roentgenogram, tumor with dense ivory bone as the main manifestation is mostly lower in malignancy, while cotton-like and spiculate tumor bone usually denotes higher degree of malignancy. The pathological basis of the radiolucent area inside the tumor, the satellite nodules in the vicinity of the tumor as well as the differential diagnosis were discussed.
Zhonghua Fang She Xue Za Zhi 1989 Jun
PMID:[The roentgen findings and pathological basis of parosteal osteosarcoma]. 258 7

Eighteen cases of osteogenic sarcoma of the long bones in the extremities were analyzed in this paper. The pathological basis of the X-ray signs was explained. It was suggested that solitary calcific shadow appearing near the knee joint in young individuals should alert the radiologist to the possibility of osteogenic sarcoma. The X-ray findings of osteogenic sarcoma were characterized by dissociation of osteolysis from ossification. Simultaneous bony destruction both inside and outside the cortex was one of the patterns of erosive bone destruction in osteogenic sarcoma. The distinction between benign and malignant bony spicules, the differences in the relationship between soft tissue mass and subcutaneous fat layer and that between osteomyelitis and the subcutaneous fat layer were discussed.
Zhonghua Fang She Xue Za Zhi 1989 Aug
PMID:[Osteogenic sarcoma (report of 18 cases)]. 262 6

A teenage girl is described who had an osteogenic sarcoma of the tibia at 11 years of age, a pulmonary metastasis at 13 years, and an intestinal leiomyosarcoma at 15 years. She remains well at the age of 18 years. Leiomyosarcoma is extremely rare in children either as a primary or secondary tumor.
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PMID:Intestinal leiomyosarcoma following treatment of osteosarcoma in a teenage girl. 264 4

Primary osteogenic sarcoma (POS) of the breast is very rare. Only eleven cases have been previously reported in Japan. In this paper, we report an additional case of POS. A 30 year old female was admitted to our hospital with chief complaint of rapidly growing mass of the right breast. She was diagnosed carcinoma of the right breast and underwent a radical mastectomy (Br + Ax + Mj + Mn). Histological findings of the resected tissues revealed POS of the breast. After three months from the operation, local recurrence was demonstrated by an incisional biopsy. One more months later, chest X-P revealed bilateral lung metastases. Irradiation with 60Co for recurrence and chemotherapy using vincristine, methotrexate for distant metastases were not effective. However, cisplatin caused the necrosis of local recurrent tumor. She died nine months after operation. At autopsy, extended metastasis of tumor cells diffusely to the pleura, lungs, liver, adrenal glands, pancreas, peritoneum, fifth lumbar vertebra, skull, dura mater and left pulmonary hilar lymph nodes was observed.
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PMID:[Primary osteogenic sarcoma of the breast. Report of a case]. 268


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