Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Growing studies have indicated the involvements of long noncoding RNAs (lncRNAs) in the initiation and progression of various tumors. We aimed to investigated the role of lncRNA
LMCD1
antisense RNA 1 (LMCD1-AS1) in
osteosarcoma
development. We found that
LMCD1
-AS1 and SP1 were highly expressed in
osteosarcoma
tissues and cell lines. High levels of
LMCD1
-AS1 were correlated with positively metastasis and poor clinical prognosis. Moreover, we showed that SP1 can bind to the promoter region of
LMCD1
-AS1, resulting in its overexpression in
osteosarcoma
. Functionally, silencing of
LMCD1
-AS1 suppressed the proliferation, migration, invasion and EMT progress of
osteosarcoma
cells. Mechanistic studies revealed that
LMCD1
-AS1 was a sponge of miR-106b-5p activity.
LMCD1
-AS1 modulated survival of
osteosarcoma
via targeting miR-106b-5p. Overall, we firstly indicated that
LMCD1
-AS1 overexpression contributes to
osteosarcoma
development and poor clinical outcome, suggesting that
LMCD1
-AS1 may be a novel diagnostic and prognostic biomarker for
osteosarcoma
and a target for
osteosarcoma
therapy.
...
PMID:SP1-mediated upregulation of lncRNA LMCD1-AS1 functions a ceRNA for miR-106b-5p to facilitate osteosarcoma progression. 3224 69
