Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0029463 (
osteosarcoma
)
16,637
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Homeobox B7
(
HOXB7
), a member of the HOX gene family, plays a role in tumorigenesis. However, until now the expression status and role of
HOXB7
in
osteosarcoma
remain unclear. Therefore, the present study aimed to investigate the functional role and mechanism of
HOXB7
in
osteosarcoma
. Our results demonstrated that
HOXB7
was overexpressed in
osteosarcoma
cell lines. Downregulation of
HOXB7
significantly inhibited
osteosarcoma
cell proliferation in vitro, as well as attenuated xenograft tumor growth in vivo. Downregulation of
HOXB7
also inhibited the migration and invasion of
osteosarcoma
cells. Furthermore, downregulation of
HOXB7
significantly suppressed the protein expression levels of p-PI3K and p-Akt in U2OS cells. In summary, our data demonstrated that downregulation of
HOXB7
inhibited proliferation, invasion, and tumorigenesis, partly through suppressing the PI3K/Akt signaling pathway in
osteosarcoma
cells. Our findings provide new insights into the role of
HOXB7
in
osteosarcoma
and new therapeutic targets for the treatment of
osteosarcoma
.
...
PMID:Downregulation of Homeobox B7 Inhibits the Tumorigenesis and Progression of Osteosarcoma. 2798 23
