Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029089 (ophthalmoplegia)
 3,338 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Transient oculomotor paralysis developed abruptly in a patient with well-documented pseudotumor cerebri. Other demonstrable causes of third-nerve palsy were excluded. Sixth-nerve palsy is known to occur in 10 to 40% of patients in most series of pseudotumor cerebri, but third-nerve palsy has not been reported previously. It may also be a nonspecific sign of raised intracranial pressure.
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PMID:Transient oculomotor paralysis in pseudotumor cerebri. 719 1

Isolated intracranial hypertension is a common manifestation of intracranial sino-venous thrombosis (ISVT). Markedly elevated intracranial tension presents with unusual features including cranial neuropathies and radiculopathy. We report two cases with ISVT, which presented with headache, papilledema, progressive visual loss, complete ophthalmoplegia and flaccid areflexic quadriparesis along with a normal sensorium. Magnetic resonance imaging (MRI) of the brain and cervical spinal cord showed no lesions that could account for the neurological deficits. Markedly elevated lumbar CSF pressure was noted in both cases. Nerve conduction study favored radiculopathy in one case and was normal in the other. Raised intracranial pressure was found to be the sole cause for the clinical manifestations. Visual impairment persisted in one patient despite lumbo-peritoneal shunting while the other died of septicemia. To our knowledge there are no previous reports of a syndrome comprising blindness, ophthalmoplegia and flaccid quadriplegia due to intracranial hypertension in ISVT.
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PMID:Blindness, ophthalmoplegia and extensive radiculopathy: an unusual clinical syndrome in intracranial sino-venous thrombosis. 1506 50

Intracranial hypertension is usually presented with papilledema and headache. Complete ophthalmoplegia without papilledema is a very rare finding of intracranial hypertension in children. A 5-year-old male patient with unilateral ophthalmoplegia due to increased intracranial pressure is presented. The fundoscopic examination and the magnetic resonance imaging of the brain were normal. He underwent lumboperitoneal shunt insertion for intracranial hypertension and the ophthalmoplegia was resolved one month later. Complete ophthalmoplegia without papilledema may occur following intracranial hypertension. Prompt and accurate diagnosis should be done and appropriate treatment to reduce the pressure should be performed to save the life of the children.
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PMID:Transient unilateral ophthalmoplegia without papilledema in a child with intracranial hypertension. 2396 Aug 95