Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0029089 (ophthalmoplegia)
 3,338 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four patients with histologically confirmed parasellar metastases are reported. The main symptoms and signs were persistent right facial pain followed by diplopia (patient 1), headache and minimal right abducens palsy (patient 2), acute, total left ophthalmoplegia (patient 3), and acute, total bilateral ophthalmoplegia (patient 4). Positive radiologic evidence was present only in patient 1: there was bony erosion of the petrous apex and computed tomography scan showed an enhanced parasellar mass. This patient underwent partial surgical removal of the tumor. Patient 3 was treated with irradiation. All patients died within 14 weeks of the onset of the initial symptoms and all were autopsied. Their primary lesions were hepatoma, stomach cancer, lung cancer, and mesenteric liposarcoma.
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PMID:Parasellar metastases: four autopsied cases. 298 Nov 20

Paraneoplastic neurological syndromes are well-known sequelae of some cancers. Based on the current literature, this is the first report of a complete ophthalmoplegia preceding the diagnosis of a myxoid liposarcoma associated with the anti-Hu antibody. An 83-year-old woman presented with a several-month history of progressive ophthalmoplegia without any other neurological symptoms or signs. After resection of her myxoid liposarcoma grade 1, her ophthalmoplegia resolved. Her paraneoplastic syndrome was associated with the anti-Hu antibody. It is important to consider an underlying malignancy when an isolated, complete ophthalmoplegia presents subacutely and when other more common aetiologies are ruled out.
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PMID:Subacute complete ophthalmoplegia: an anti-Hu paraneoplastic manifestation of myxoid liposarcoma. 1765 Dec 57